NFL Betting Odds: Week 2 Expert Picks, Props, and Parlays | BUSR

NFL
September 12, 2025

At BUSR, we’re breaking down the top NFL games to bet on this Sunday Night, complete with NFL odds, against-the-spread (ATS) trends, expert betting predictions, and parlay/prop angles to help you cash in.

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Buffalo Bills (-7) at New York Jets

 

Betting Outlook

The Buffalo Bills are laying a full touchdown on the road, but their defense remains a concern. Dating back to last season, Buffalo ranked just 24th in defensive EPA per drive after Week 9. In Week 1, they were gashed by Baltimore’s ground game and looked vulnerable to explosive plays.

The New York Jets showed a surprising offensive rhythm in their opener. Justin Fields, often criticized for holding the ball too long, looked poised in the pocket and used his legs strategically to extend drives. If he continues to limit sacks, this Jets offense has the balance to challenge Buffalo.

Trends

  • The New York Jets are 5-2 ATS in their last seven home games as underdogs.
  • Buffalo has failed to cover in five of their last seven road games.

 

Expert Prediction

This line feels inflated. The Jets at +7 are live at home, especially if they establish the run and slow the pace.

  • ATS Lean: Jets +7
  • Parlay Angle: Jets +7 with Under 45.5
  • Prop Bet: Justin Fields Over 46.5 rushing yards

 

Philadelphia Eagles (-1.5) at Kansas City Chiefs

 

Betting Outlook

This Super Bowl rematch comes early in the season, but both teams showed flaws in Week 1. Jalen Hurts struggled against Dallas’ soft zone, failing to anticipate throws in tight windows. Against Steve Spagnuolo’s aggressive man-coverage looks, the Philadelphia Eagles offense will be forced to stretch the field more.

The Kansas City Chiefs’ defense, however, was shredded by the Los Angeles Chargers, giving up explosive plays at will. If Spagnuolo doesn’t adjust, the Eagles’ receivers could feast.

 

Trends

  • Patrick Mahomes is 9-3 ATS as a home underdog or pick’em.
  • The Under has hit in 5 of the last 6 meetings between these teams.

 

Expert Prediction

This is shaping up as a defensive chess match. While Mahomes can keep KC alive, Philly’s defense matches up well against the short passing game.

  • ATS Lean: Chiefs +1.5 or tease to +7
  • Total: Under 47
  • Prop Bet: Jalen Hurts Anytime TD

 

Los Angeles Rams (-5.5) at Tennessee Titans

Betting Outlook

The Rams’ offensive line is battered, and facing Tennessee’s elite front seven without two starting guards spells trouble for Matthew Stafford. Tennessee limited Denver to just 4.0 yards per pass attempt in Week 1 and ranked top-5 in pressure rate.

Cam Ward’s NFL debut wasn’t spectacular on paper, but the rookie showed poise against a tough defense. With JC Latham trending towards playing, Tennessee should be more balanced on offense.

 

Trends

  • Titans are 11-4 ATS as underdogs since 2023.
  • The Rams are 2-6 ATS in their last eight road games.

 

Expert Prediction

Tennessee thrives in ugly, grind-it-out games. With LA’s O-line compromised, the Titans are a sharp side.

  • ATS Lean: Titans +5.5 (sprinkle ML)
  • Parlay Angle: Titans +5.5 & Under 42.5
  • Prop Bet: Stafford Over 0.5 interceptions

 

Carolina Panthers at Arizona Cardinals (-6.5)

Betting Outlook

Carolina’s defense is a liability. In Week 1, they gave up 200 rushing yards at 6.3 yards per carry, continuing a trend that made them the league’s worst run defense in 2024. That sets up perfectly for Arizona, which ranked 7th in rushing EPA per play last year.

Bryce Young continues to struggle with consistency, and without a reliable pass rush to slow down Kyler Murray, this could spiral quickly.

 

Trends

  • Panthers are 2-7 ATS in their last nine road games.
  • Arizona is 5-2 ATS in its last seven home games as favorites.

 

Expert Prediction

At home against one of the league’s weakest rosters, Arizona is worth laying points.

  • ATS Lean: Cardinals -6.5
  • Prop Bet: James Conner Over 74.5 rushing yards
  • Parlay Angle: Cardinals -6.5 with Conner Anytime TD

 

Los Angeles Chargers (-3.5) at Las Vegas Raiders

Betting Outlook

Both offenses flashed explosiveness in Week 1. The Chargers went surprisingly pass-heavy, finishing with a top-3 passing success rate, while the Raiders led the NFL in explosive pass rate against the New England Patriots.

Defensively, Vegas impressed under Patrick Graham, shutting down the Patriots and creating turnovers. If they slow down Herbert’s deep game, they can cover at home.

 

Trends

  • Raiders are 4-1 ATS in their last five divisional home games.
  • The Chargers are 1-5 ATS in their last six as road favorites.

 

Expert Prediction

This divisional matchup screams volatility. Getting +3.5 with the Raiders at home is the sharp side.

  • ATS Lean: Raiders +3.5
  • Prop Bet: Davante Adams Over 85.5 receiving yards

 

Quick Hits: Other Betting Angles

  • Bears +6.5 vs. Lions → Detroit is struggling to generate explosive plays.
  • Colts +2.5 vs. Broncos → Lou Anarumo’s defense looks improved.
  • Bucs/Texans Under 42.5 → both offensive lines are a liability.

 

BUSR Best Bets Parlay (Week 2 Special)

  • Jets +7
  • Titans +5.5
  • Raiders +3.5
  • Cardinals -6.5

 

Payout around +1100 depending on market movement.

 

Props Spotlight

  • Justin Fields Over rushing yards (40s range)
  • Jalen Hurts Anytime TD
  • James Conner Over rushing yards (70s range)
  • Davante Adams Over receiving yards (85+)

 

Final Word

Week 2 is where the betting market is most vulnerable. Overreactions to Week 1 results inflate lines, allowing sharp bettors to exploit them. At BUSR, we’ve highlighted where spreads are too high, where underdogs have live value, and which props provide sneaky angles.

If you’re looking to place your bets on NFL Week 2 odds, BUSR offers early lines, live betting, team props, and same-game parlays. This Sunday slate is full of edges — it’s time to take advantage.

 

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