Thursday Night Football Odds: Week 2 – Detroit Lions at Buffalo Bills
The Amazon Prime Video-branded Thursday Night Football season kicks off September 17 (Week 2) with a proper stadium party: the Detroit Lions, looking to rebound from a stunning fall to 9-8 last season, crash Buffalo‘s brand-new Highmark Stadium for its christening under first-year head coach Joe Brady. Week 1 also had its own Thursday game, an international matchup on Netflix separate from this package. Live spread, moneyline, and total below, updated continuously until kickoff at BUSR, with player props and AFC East futures live once posted, plus Super Bowl LXI odds if you’re thinking bigger picture. This page refreshes every week with the current TNF game, storylines, and player props. Looking for the full season schedule instead? Check the Thursday Night Football hub page or the complete NFL schedule.
Thursday Night Football Odds
Lions at Bills, Thursday, September 17. Odds updated daily at BUSR.ag.
VS
| Team | Spread | Moneyline | Total |
|---|---|---|---|
| Detroit Lions | +3-110 | N/ANot yet posted | O 51.5-110 |
| Buffalo Bills | -3-120 | N/ANot yet posted | U 51.5-110 |
Moneyline not yet posted for this matchup. Spread and total confirmed via BUSR.ag.
Lions at Bills: Week 2 Storylines
Buffalo christens its brand new Highmark Stadium in Week 2, with Joe Brady taking over as head coach after Sean McDermott was fired following a 12-5 season that ended in a Divisional Round loss.
The Lions slid from a 15-2, NFC North-winning 2024 to a 9-8, last-place finish in 2025 after losing both coordinators, Ben Johnson and Aaron Glenn, to head coaching jobs. New offensive coordinator Drew Petzing arrives from Arizona to install a tight end-friendly scheme.
Josh Allen now throws to a receiving room reshaped by the DJ Moore trade, while Jared Goff, Jahmyr Gibbs, Amon-Ra St. Brown and a healthy Sam LaPorta anchor a Lions offense that finished top five in scoring even amid the turmoil.
Player Prop Probables: Lions at Bills
Player props aren’t posted yet for this matchup. Here are the probable markets to watch once lines open at BUSR.
Probable market for Buffalo’s dual-threat quarterback, now with DJ Moore added to a retooled receiving room for the stadium opener.
Probable market for Detroit’s quarterback under new offensive coordinator Drew Petzing, who arrives with a tight end-friendly scheme built around Sam LaPorta.
Probable market for Buffalo’s lead back, coming off a league-leading 1,621-yard rushing season in 2025.
Full player prop board and same-game parlay builder live at BUSR once lines open for Lions vs Bills. See the NFL Prop Bets page for the full league-wide prop menu.
Thursday Night Football Odds FAQ
How often do Thursday Night Football odds update?
This week’s TNF spread, moneyline, and total are posted days before kickoff and update continuously at BUSR right up until the game starts, then convert to live in-game odds once the ball is kicked off.
Where can I see the full Thursday Night Football schedule?
The complete 2026 Thursday Night Football schedule, all 16 games plus the full Thanksgiving slate, is available on the Thursday Night Football hub page at BUSR.
Can I bet TNF props at BUSR?
Yes. Player props for both starting quarterbacks, the top skill-position players on each roster, and same-game parlays are all available for every Thursday Night Football matchup.
Is live betting available during Thursday Night Football?
Yes. BUSR offers live in-game betting for every Thursday Night Football game. Spreads, moneylines, and totals update in real time on every possession.
Can I bet Thursday Night Football at BUSR?
Yes. BUSR posts spreads, moneylines, totals, player props, and live betting for every Thursday Night Football game, including Thanksgiving. New members get $500 when they place their first $50 bet. Minimum deposit: $50. Lines update daily through the 2026-27 season at BUSR.
NFL Betting Odds:
NFL Game Odds | Super Bowl LXI Odds to Win | NFL 1st Half Lines | NFL 2nd Half Lines | NFL Quarter Lines
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