NFL Picks: Week 10 Jaguars vs 49ers


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This Sunday, the San Francisco 49ers and Jacksonville Jaguars are set to square off in Week 10 of the NFL at EverBank Stadium, providing bettors with an intriguing matchup to consider.


Spread: 49ers -3 (-109), Jaguars +3 (-111) 

Moneyline: 49ers -165, Jaguars +145 

Total: O 45 (-111), U 45 (-109) 


San Francisco 49ers

NFL Team San Francisco 49ersThe 49ers are eager to break their three-game losing streak. With a split record in their last four on the road, they’re at a crossroads. Quarterback Brock Purdy has shown efficiency, completing 68.3 percent of his passes for over 2,000 yards, and with the support of receivers like Brandon Aiyuk and George Kittle, the team’s aerial game is strong. The 49ers’ running game, led by the dynamic Christian McCaffrey, averages 133.5 yards per game, which is significant for bettors tracking offensive consistency. On defense, they’re holding opponents to 17.5 points per game on average, with Fred Warner and Charvarius Ward as standout players. Notably, the 49ers have a history of success against winning teams and covering the spread in Week 10 games, which could bode well for them.


Jacksonville Jaguars

NFL Team Jacksonville JaguarsThe Jaguars, on a high with a five-game winning streak, face the challenge of translating their success to their home field, where they’ve recently had mixed results. Trevor Lawrence has been matching Purdy’s completion rate, throwing for 1,935 yards. His targets, Christian Kirk and Evan Engram, have been reliable, and the Jaguars’ ground game, with Travis Etienne Jr., is not far behind the 49ers, averaging 112.5 yards per game. Jacksonville’s defense allows slightly more points per game than San Francisco’s, but with top tackler Foyesade Oluokun and pass rusher Josh Allen, they’re no pushover. Their record against teams with winning records is strong, both on Sundays and against the spread, which is an encouraging sign for bettors leaning toward the Jaguars.



The prediction leans towards the Jaguars, not just for their current form, but also for their offensive speed that could challenge the 49ers’ defense. With both teams coming off a bye week, freshness won’t be an advantage, but Jacksonville’s momentum and their performance in scoring defense, being ninth in the league, give them an edge. Plus, with the Jaguars back at home after international games, they have the opportunity to leverage home advantage and the points spread. For those betting on this game, the Jaguars might offer the value play on BUSR’s NFL Odds, especially with the potential benefit of the home field and a free-field goal spread underdog status.