NFL Picks: Week 12 Seahawks vs 49ers


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The NFL’s Week 12 is heating up with a fierce NFC West rivalry as the San Francisco 49ers, armed with a two-game winning streak, head into the state of Washington to take on the Seattle Seahawks. Both teams are fighting for the division, making this matchup a critical pivot point in the race for the playoffs. With the 49ers favored to win, all eyes will be on this high-stakes contest that promises to deliver intense action.



Spread: 49ers -6.5 (-115), Seahawks +6.5 (-105) 

Moneyline: 49ers -300, Seahawks +240 

Total: O 43 (-113), U 43 (-107) 

San Francisco 49ers

NFL Team San Francisco 49ersThe San Francisco 49ers are set to continue their impressive 7-3 run as they head into a pivotal Week 12 matchup against the Seattle Seahawks. With a flawless 2-0 divisional record and a strong 4-1 stance in home games, the 49ers are hitting the road where they’ve maintained a solid 3-2 record. They are one of the Super Bowl favorites, no discussion. 

Fresh off a convincing 27-14 victory over the Buccaneers, the 49ers are looking to quarterback Brock Purdy to maintain his stellar performance after a 333-yard, 3-touchdown game with no interceptions. Running back Christian McCaffrey and receiver Brandon Aiyuk have been key offensive weapons, while their defense, led by Fred Warner and powerhouse pass rushers like Nick Bosa, is proving formidable. 

Seattle Seahawks

NFL Team Seattle SeahawksThe Seahawks, with a 6-4 overall record, are facing a tougher stretch. Despite a strong 4-1 home record, they’re 1-2 in divisional games and have experienced a narrow 17-16 defeat to the Rams in their last outing, they were favorites. Quarterback Geno Smith, who has been a revelation this season, will be crucial for the Seahawks’ success, along with the explosive play of receivers like DK Metcalf. The defense, with standouts like Quandre Diggs and the rookie sensation Tariq Woolen, will need to step up against the high-powered 49ers offense facing the toughest challenge of the season yet for the Seahawks. 



As the 49ers are listed as a 6.5-point favorite, they’re in a prime position to take control of the NFC West with a win. The Seahawks have been competitive in their recent games, but they’ve been cutting it close, with outcomes often hinging on the final drive. With the 49ers coming out strong from their bye week and the Seahawks struggling in division games, the smart bet is on the 49ers to cover the spread on BUSR’s NFL Odds and potentially tighten their grip on the division lead.