NFL Picks: Week 4 Cardinals vs 49ers


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In a Sunday NFL clash at Levi’s Stadium, the Arizona Cardinals face off against the San Francisco 49ers. Here’s an overview of the matchup along with our prediction. 



Spread: Cardinals +14 (-110), 49ers -14 (-110) 

Moneyline: Cardinals +635, 49ers -950

Total: O 44.5 (-110) , U 44.5 (-110) 


san francisco 49ersSan Francisco 49ers

The 49ers have been in fine form, boasting a perfect 3-0 record so far this season. They started with a commanding win over the Steelers, followed by a competitive victory against the Rams. In their most recent game against the Giants, the 49ers dominated with a 30-12 win. QB Brock Purdy threw for 310 yards and two touchdowns, while Christian McCaffrey added 85 rushing yards and a TD. Deebo Samuel was a standout performer with six receptions for 129 yards and a score. 

The 49ers have a strong track record on the West Coast, winning each of their last 13 games played there. They’ve also covered the spread in each of their last 12 home games against NFC opponents.


Arizona Cardinals

The Cardinals had a rocky start to the season, suffering losses in their first two games against the Commanders and the Giants. In both of these losses, they struggled in the fourth quarter. However, in their recent matchup against the Cowboys, the Cardinals pulled off a surprising upset with a 28-16 victory. 

Joshua Dobbs led the way with 189 passing yards and a touchdown, while James Conner contributed 98 rushing yards and another TD. Michael Wilson had a notable performance with two receptions for 86 yards. It’s worth noting that the Cardinals have struggled in their last six games when playing with a rest disadvantage. The underdogs have covered the spread in nine of the Cardinals’ last 10 Week 4 games.


While the line may tempt some to consider the Cardinals, we’re sticking with the San Francisco 49ers. The 49ers have navigated challenging situations this season and emerged with an impressive 3-0 record. Their defense showed its prowess against the Giants, limiting them to just 150 yards and 10 first downs. With extra rest days, the 49ers should enter this matchup in top form.

The Cardinals, on the other hand, are coming off a strong performance against the Cowboys, but we expect them to face a tougher challenge against the 49ers. The 49ers have the momentum and the home advantage, making them the more favorable pick in this game. While the Cardinals may not perform poorly, we anticipate the 49ers to cover the massive -14 spread in BUSR NFL Odds and secure the win. Look for the 49ers to continue their strong start to the season.