3 Best Bets: Ravens vs Bills SNF Week 1

NFL
September 7, 2025

Week 1 of the NFL season wraps up with a blockbuster Sunday Night Football matchup, as the Buffalo Bills host the Baltimore Ravens at Highmark Stadium. These two AFC contenders met in last year’s Divisional Round, where Buffalo narrowly escaped with a 27–25 victory. That game wasn’t decided until the final moments, and it reminded fans of just how evenly matched these squads are.

Fast forward to the 2025 season, and expectations are sky-high once again. The over/under is set at 50.5 points, the highest total of the entire Week 1 slate, and Buffalo enters as a slim home favorite. The betting market is projecting fireworks, with both Josh Allen and Lamar Jackson looking to kick off their MVP campaigns in style.

With so many weapons on both sidelines, from Derrick Henry and Mark Andrews for Baltimore to Stefon Diggs and James Cook for Buffalo, there’s no shortage of intriguing betting options. To help you get the most out of this primetime showdown, here are our three best bets for Ravens vs. Bills on Sunday Night Football.

1. Over 50.5 Total Points

Sometimes, the simplest bet is the smartest one. Oddsmakers didn’t set the highest total of Week 1 by accident. These two offenses are built to score, and the conditions for another shootout are firmly in place.

Baltimore averaged 24.7 points per game last season and bolstered its attack by adding Derrick Henry, who instantly upgrades their red-zone efficiency. Meanwhile, Lamar Jackson continues to improve as a passer, spreading the ball to a deeper receiving corps while still maintaining his trademark rushing ability.

The Bills remain one of the most dangerous teams in the league behind Josh Allen. They finished top 10 in both points and yards last season, and Allen himself accounted for 44 total touchdowns (29 passing, 15 rushing). Buffalo has consistently leaned on his playmaking when games are on the line, and that trend isn’t likely to change.

In last year’s playoff clash, these teams combined for 52 points. With even more firepower on the field this year and both defenses facing questions, particularly in the secondary, this matchup is primed to clear the total again.

The over is the play, and it’s our strongest bet for this game.

2. Derrick Henry Anytime Touchdown (-154)

There are few certainties in NFL betting, but Derrick Henry finding the end zone has been about as close as it gets. The 6’2”, 252-pound running back tied for the NFL lead with 16 rushing touchdowns last year, continuing a streak of seven straight seasons with double-digit scores.

Now, he’s wearing purple and black. Baltimore didn’t bring Henry in just to split carries, they plan to unleash him in short-yardage and goal-line situations where he’s been virtually unstoppable. Against Buffalo specifically, Henry has been a nightmare. In two meetings last season (including playoffs), he scored three touchdowns and averaged over 80 total yards per game.

Henry scored in 15 of 19 games last year, and given his track record, -154 odds are more than reasonable. While it won’t deliver a huge payout on its own, Henry’s consistency makes him the perfect anchor for parlays or as a reliable single bet.

If you’re betting anytime touchdown props, Henry should be at the top of your list.

3. Josh Allen Over 1.5 Passing Touchdowns

While much of the focus on Josh Allen centers around his ability to run, he’s equally dangerous through the air. He threw for 29 touchdowns last season, and in five of his six career Week 1 starts, he’s thrown at least two passing scores. Allen tends to shine brightest in season openers, setting the tone for Buffalo’s offense.

The Ravens’ defense has plenty of talent, but their secondary showed cracks against top-tier quarterbacks last season, especially in the postseason. Allen has historically played well against Baltimore, using play-action and his mobility to extend drives. With Stefon Diggs still leading the wide receiver room and younger options like Khalil Shakir and Ray Davis stepping into larger roles, Allen has enough weapons to spread the ball around.

In a game with such a high total, the Bills are going to need multiple touchdowns through the air to keep pace. The odds on Allen to throw over 1.5 passing TDs present strong value, especially given his Week 1 track record.

Expect Allen to air it out and deliver at least two scores.

Final Thoughts

The Ravens vs. Bills matchup is a perfect way to close out the NFL’s opening week, a battle between two Super Bowl hopefuls led by MVP-caliber quarterbacks. Both teams are capable of explosive scoring runs, and oddsmakers are bracing for a shootout.

Our three best bets for Sunday Night Football are:

  • Over 50.5 Total Points

  • Derrick Henry Anytime Touchdown (-154)

  • Josh Allen Over 1.5 Passing Touchdowns

This game has all the ingredients to be one of the most exciting contests of Week 1, and bettors should take advantage of the opportunities it provides. Whether you’re looking for a safe play with Henry, a value-driven passing prop on Allen, or simply trusting the over, there’s a bet here for every style.

You can lock in all your wagers for Ravens vs. Bills SNF Week 1 right here at BUSR, your trusted destination for NFL betting all season long.

 

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