NFL Week 16 Odds: Early Lines Bettors Should Grab Now
With the fantasy NFL playoffs in full swing and the NFL postseason picture sharpening, Week 16 brings us a loaded slate that includes Thursday Night Football, a Saturday double-header, and a massive Sunday of action.
BUSR has released the opening lines, and sharps are already circling the numbers that look “soft.” In this betting market, timing is everything. A spread of -6.5 can quickly turn into -7.5 by kickoff, destroying your value.
Based on the opening NFL odds from BUSR and the latest injury reports, here are the early lines you should look to grab right now before the public moves them.
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1. Detroit Lions (-6.5) vs. Pittsburgh Steelers
- – Current Line: Lions -6.5 (-115)
- – Why You Should Bet It Now: Despite a tough 41–34 loss to the Rams last Sunday, the oddsmakers are showing massive respect to the Lions (8–6). The Detroit Lions are returning to Ford Field for their final home game of the season, a venue where they have historically thrived.
- – The “Grab Now” Factor: This line reflects confidence in Detroit’s explosive offense. Jared Goff, Amon-Ra St. Brown, and Jameson Williams all put up huge numbers against the Rams, proving the offense is clicking even if the win-loss column wobbled.
- – Meanwhile, the Pittsburgh Steelers (7–6) are in a brutal spot—they have to play the Dolphins on Monday Night Football before traveling on a short week to face a rested Detroit team. Dan Campbell’s “don’t go numb to losing” message is expected to light a fire under this squad. Grab the -6.5 before the public reacts to a fatigued Steelers team and pushes this to -7.
2. Philadelphia Eagles (-6) vs. Washington Commanders
- – Current Line: Eagles -6 (-110)
- – Why You Should Bet It Now: Both teams snapped losing streaks on Sunday, but in very different fashions. The Commanders ended an eight-game skid with a gritty 29–21 win over the Giants, while the Eagles finally looked like contenders again, breaking a three-game slump by shutting out the Raiders 31–0.
- – The “Grab Now” Factor: While the Eagles haven’t looked like the dominant force of last year, a 31–0 shutout signals a defensive resurgence at the perfect time.
- – Washington may have momentum, but they struggled to put away a bad Giants team. The market is pricing the Eagles as the superior team, and with the Commanders’ defense still suspect, this -6 spread offers a layer of protection before it potentially climbs to the key number of 7.
3. Green Bay Packers (-1.5) vs. Chicago Bears
- – Current Line: Packers -1.5 (-110)
- – Why You Should Bet It Now: This Saturday showdown is effectively for the NFC North division title. The Bears reclaimed first place with a dominant 31–3 blowout of the Browns, while the Packers fell to the Broncos 34–26.
- – The “Grab Now” Factor: This line is highly volatile due to massive injury news. The Packers may have lost All-Pro pass rusher Micah Parsons to a torn ACL and saw WR Christian Watson leave in an ambulance (chest).
- – On the Chicago side, rookie WR Luther Burden III (ankle) and Rome Odunze (foot) are banged up.
- – If Green Bay’s injury fears regarding Parsons and Watson are confirmed, this line will almost certainly swing toward Chicago. If you like the Bears, grabbing points (or the moneyline) against a battered Packers defense is a high-value play right now.
NFL Week 16 Opening Odds Board
Thursday, December 18
| Matchup | Spread | Moneyline | Total |
| Los Angeles Rams | -1.5 (-110) | -124 | O 44.5 |
| Seattle Seahawks | +1.5 (-110) | -103 | U 44.5 |
Saturday, December 20
| Matchup | Spread | Moneyline | Total |
| Philadelphia Eagles | -6 (-110) | -265 | O 45 |
| Washington Commanders | +6 (-110) | +200 | U 45 |
| Green Bay Packers | -1.5 (-110) | -134 | O 47 |
| Chicago Bears | +1.5 (-110) | +105 | U 47 |
Sunday, December 21 (Early Games)
| Matchup | Spread | Moneyline | Total |
| Buffalo Bills | -10 (-110) | -599 | O 42.5 |
| Cleveland Browns | +10 (-110) | +400 | U 42.5 |
| Kansas City Chiefs | -3.5 (-105) | -197 | O 37.5 |
| Tennessee Titans | +3.5 (-115) | +152 | U 37.5 |
| Tampa Bay Buccaneers | -2.5 (-110) | -150 | O 46 |
| Carolina Panthers | +2.5 (-110) | +117 | U 46 |
| New York Jets | +4 (-110) | +170 | O 40 |
| New Orleans Saints | -4 (-110) | -222 | U 40 |
| Cincinnati Bengals | +1.5 (-110) | -102 | O 50.5 |
| Miami Dolphins | -1.5 (-110) | -125 | U 50.5 |
| Minnesota Vikings | -2.5 | N/A | O 44.5 |
| New York Giants | +2.5 | N/A | U 44.5 |
| Los Angeles Chargers | +0.5 | N/A | O 48.5 |
| Dallas Cowboys | -0.5 | N/A | U 48.5 |
Sunday, December 21 (Late Games)
| Matchup | Spread | Moneyline | Total |
| Jacksonville Jaguars | +3 (-110) | +123 | O 45.5 |
| Denver Broncos | -3 (-110) | -158 | U 45.5 |
| Atlanta Falcons | -2 (-110) | -133 | O 46.5 |
| Arizona Cardinals | +2 (-110) | +105 | U 46.5 |
| Las Vegas Raiders | +14 (-110) | +760 | O 37.5 |
| Houston Texans | -14 (-110) | -1695 | U 37.5 |
| Pittsburgh Steelers | +6.5 (-105) | +232 | O 49.5 |
| Detroit Lions | -6.5 (-115) | -319 | U 49.5 |
Sunday Night Football
| Matchup | Spread | Moneyline | Total |
| New England Patriots | +2.5 (-110) | +116 | O 48 |
| Baltimore Ravens | -2.5 (-110) | -148 | U 48 |
Monday Night Football (Dec 22)
| Matchup | Spread | Moneyline | Total |
| San Francisco 49ers | -5.5 (-110) | -248 | O 46.5 |
| Indianapolis Colts | +5.5 (-110) | +180 | U 46.5 |
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