How to Bet on NFL Week 4: Odds, Lines and Totals For All Games

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Week 4 NFL Predictions: Odds are Heating Up

Week 3 of the NFL season shook things up. Underdogs cashed, favorites crashed, and the board reminded us why the NFL is the toughest league to bet. That chaos is the hook, but it also makes sharp analysis essential. Whether you’re a veteran bettor or new to the action, this breakdown covers every matchup with injury reports, live odds, and our best Week 4 predictions.

Last week flipped the script. The Browns handed Green Bay its first loss in a nail-biter, while the Bears dominantly stunned the Cowboys. Those swings reset early-season narratives and, more importantly, opened the door to market overreactions. Week 4 is the time to cut through the noise and spot real value.

Sunday Night Football headlines the slate. Packers vs. Cowboys is now a proving ground—Dallas hunting redemption, Green Bay trying to show the stumble was just a bump. Get this matchup right, and the rest of the card falls into place. From that clash to every game on the schedule, we’ll break down where the numbers don’t match reality and where bettors can strike.

Thursday Night Football, September 25: Seattle Seahawks at Arizona Cardinals

• Venue: State Farm Stadium, Glendale, Arizona
• Date: Thursday, September 25, 2025
• Time: 8:15 PM ET

Team Analysis and Betting Breakdown

The Seattle Seahawks come into this game with momentum after a resounding 44-13 victory over the Saints in Week 3. Quarterback Sam Darnold is playing some of the best football of his career, and the Seahawks’ defense looked dominant. Their offense is firing on all cylinders, and they’re playing with a high level of confidence. However, they face a short week and a divisional opponent. The Seahawks are currently dealing with several injuries, including key players on defense like corner Devon Witherspoon and safeties Julian Love and Nick Emmanwori, who were all limited in practice. Their running back, Zach Charbonnet, was a full participant, which is a good sign for their ground game.

On the other side, the Arizona Cardinals are reeling from a close 16-15 loss to the 49ers. The most significant blow from that game was the season-ending ankle injury to star running back James Conner. This injury completely changes the dynamic of their offense, placing a substantial amount of pressure on quarterback Kyler Murray. Rookie running back Trey Benson will now step into a featured role, a tough ask against an improving Seattle defense. The Cardinals also have several players on their injury report, including offensive linemen Paris Johnson Jr. and Will Hernandez, who were limited in practice. This could spell trouble for their offensive line against Seattle’s pass rush.

The Pick: Seattle Seahawks (-1) The Seahawks are hot, and the Cardinals are dealing with a significant injury to their offensive centerpiece. The line has already moved in Seattle’s favor, but the Seahawks still offer good value. Their offense is humming, and their defense is playing with a newfound aggressiveness. They handle business on a short week and cover the spread.

• Spread: Cardinals -1
• Moneyline: Cardinals -104, Seahawks +118
• Total: 43.5

Sunday, September 28: Minnesota Vikings vs. Pittsburgh Steelers

• Venue: Croke Park, Dublin, Ireland
• Date: Sunday, September 28, 2025
• Time: 9:30 AM ET

Team Analysis and Betting Breakdown

The Minnesota Vikings are coming off a statement win, a 48-10 rout of the Bengals. It was a massive performance for their offense, led by their rookie quarterback. The Vikings are a well-coached team and have looked solid on both sides of the ball. They are 2-1 against the spread this season, consistently outperforming expectations. They are also playing on a neutral site, which might negate some of the Steelers’ home-field advantage. Running back Ty Chandler and wide receiver Rondale Moore are both out with injuries, which could impact the Vikings’ offensive flow, but the team has proven it can overcome these challenges.

The Pittsburgh Steelers are riding the high of a 21-14 victory over the Patriots, snapping out of a scoring funk. Quarterback Aaron Rodgers is finding his rhythm with his new team, but they’ve struggled to cover this season with a 1-2 ATS record. The Steelers’ defense has the potential to be elite, but they’ve had some shaky moments. Injuries are a concern for them, as they have several key players on their report, including cornerback Joey Porter Jr., who is questionable with a hamstring injury, and star defensive end Alex Highsmith, who is also doubtful with an ankle injury.

The Pick: Minnesota Vikings (-2.5) The Vikings have a proven track record of beating the spread this season, and their offense looked explosive in Week 3. While the Steelers got a win, it was an ugly one, and their offense still looks inconsistent. The neutral site also favors the more polished Vikings. I’m confident they handle their business in Dublin.

• Spread: Vikings -2.5
• Moneyline: Vikings -154, Steelers +120
• Total: 41

Sunday, September 28: Washington Commanders at Atlanta Falcons

• Venue: Mercedes-Benz Stadium, Atlanta, Georgia
• Date: Sunday, September 28, 2025
• Time: 1:00 PM ET

Team Analysis and Betting Breakdown

The Washington Commanders got back on track with a dominant 41-24 victory over the Raiders. They showed a balanced attack on offense and a disruptive defense. Rookie quarterback Jayden Daniels, who missed Week 3, is a crucial piece to their offense, and his status will be a key factor in this game. If he plays, the Commanders have a dynamic threat. However, their injury report also lists wide receiver Terry McLaurin with a quad injury, which could significantly impact their passing game. The Commanders have a strong defense that is capable of creating turnovers.

The Atlanta Falcons, on the other hand, are in a complete freefall. They were shut out 30-0 by the Panthers in Week 3, and quarterback Michael Penix Jr. had a terrible outing, throwing two interceptions. The Falcons’ offense has been stagnant, and they’ve shown little ability to move the ball consistently. They are struggling with injuries on both sides of the ball. With players like cornerback A.J. Terrell Jr. and wide receiver Jamal Agnew questionable, their struggles could continue.

The Pick: Washington Commanders (-2.5). The Falcons’ offense looks completely lost right now. Their shutout loss in Week 3 was embarrassing, and it’s hard to see them turning it around against a motivated Washington team. The Commanders are playing with confidence, and their defense will likely feast on a struggling Falcons offense. Even if Jayden Daniels doesn’t play, the Commanders have enough pieces to win this one handily. We’re picking the Commanders to cover the spread.

• Spread: Commanders -2.5
• Moneyline: Commanders -148, Falcons +116
• Total: 45.5

Sunday, September 28: New Orleans Saints at Buffalo Bills

• Venue: Highmark Stadium, Orchard Park, New York
• Date: Sunday, September 28, 2025
• Time: 1:00 PM ET

Team Analysis and Betting Breakdown

The Buffalo Bills are a perfect 3-0 and a legitimate Super Bowl contender. They have been dominant, scoring over 30 points in all three games and committing no turnovers. Quarterback Josh Allen is playing at an MVP level. The Bills have an incredibly talented offense and a defense that can suffocate opponents. They are also playing at home, where they have a massive advantage. While they have a few injuries, including a questionable status for linebacker Matt Milano, their depth is incredible, and they are not expected to be slowed down.

The New Orleans Saints are struggling, sitting at 0-3 on the season. They have lost two games heartbreakingly and were completely blown out by the Seahawks in Week 3. Their offense has been inconsistent, and their defense has struggled to make key stops. Injuries are a major concern, as several key players are on the injury report. They are facing an incredibly tough matchup on the road against one of the best teams in the NFL.

The Pick: Buffalo Bills (-16.5). This is the biggest spread of the week for a reason. The Bills are playing at an elite level, while the Saints appear to be one of the worst teams in the league. The Saints’ offense has no answer for the Bills’ defense, and the Bills’ offense will score at will. Buffalo will run up the score and cover this massive spread with ease.

• Spread: Bills -16.5
• Moneyline: Bills -2019, Saints +859
• Total: 48.5

Sunday, September 28: Cleveland Browns at Detroit Lions

• Venue: Ford Field, Detroit, Michigan
• Date: Sunday, September 28, 2025
• Time: 1:00 PM ET

Team Analysis and Betting Breakdown

The Cleveland Browns are coming off a massive 13-10 victory over the Green Bay Packers. Their defense was incredible, getting a late blocked field goal to seal the win. However, their offense remains a concern, especially with quarterback Deshaun Watson still out with an ankle injury. They also have several key players on their injury report, including defensive tackle Mike Hall Jr. and linebacker Jeremiah Owusu-Koramoah, who are both questionable. The Browns’ defense is their strength, and they will need another huge performance to stay in this game.

The Detroit Lions bounced back from their Week 2 loss with a massive 52-21 win over the Bears and a Coach Campbell “strategic masterplan” yesterday against the Ravens. Quarterback Jared Goff threw five touchdown passes, and the offense looked unstoppable. The Lions have a dynamic offense with multiple playmakers, and they are playing at home, where they are a tough out. They also have a relatively clean injury report, which is a significant advantage.

The Pick: Detroit Lions (-8.5) The Lions’ offense is humming, and the Browns’ offense is stagnant. The Browns’ defense is good, but it’s hard to see them stopping the Lions’ offense for four quarters, especially with their own struggles on offense. The Lions will get out to an early lead and never look back. I’m picking the Lions to cover the spread.

• Spread: Lions -8.5
• Moneyline: Lions -505, Browns +345
• Total: 45.5

Sunday, September 28: Carolina Panthers at New England Patriots

• Venue: Gillette Stadium, Foxborough, Massachusetts
• Date: Sunday, September 28, 2025
• Time: 1:00 PM ET

Team Analysis and Betting Breakdown

The Carolina Panthers are coming off a 30-0 shutout victory over the Falcons. They were able to capitalize on the Falcons’ turnovers and play good defense. While the win was impressive, their offense still needs to prove it can consistently move the ball against a better team. The Panthers have their own injury concerns, with rookie wide receiver Xavier Legette and tight end Ja’Tavion Sanders both listed as questionable.

The New England Patriots suffered a 21-14 loss to the Steelers, turning the ball over five times. It was a challenging game for them, but they showed some fight by battling back to tie it at one point. The Patriots’ offense has performed better than expected, but their turnover issues remain a significant problem. They also have some injuries to monitor, with linebacker Patrick Jones II and wide receiver Kendrick Bourne both questionable.

The Pick: New England Patriots (-5.5) “The Pats” are at home, and they are a better team than their record suggests. Their offense has been moving the ball well, but the Panthers’ offense remains a question mark. I expect the Patriots to clean up their turnover issues and capitalize on the Panthers’ inexperience.

• Spread: Patriots -5.5
• Moneyline: Patriots -255, Panthers +192
• Total: 43.5

Sunday, September 28: Los Angeles Chargers at New York Giants

• Venue: MetLife Stadium, East Rutherford, New Jersey
• Date: Sunday, September 28, 2025
• Time: 1:00 PM ET

Team Analysis and Betting Breakdown

The Los Angeles Chargers are one of the surprise teams of the 2025 season, sitting at 3-0. They are a perfect 2-0-1 against the spread and are playing with a newfound confidence. Quarterback Justin Herbert is playing like an MVP candidate, and the Chargers’ offense is elite. They suffered a significant blow in Week 3 with the season-ending Achilles injury to running back Najee Harris, but rookie Omarion Hampton is expected to step up.

The New York Giants are in a tough spot, sitting at 0-3 on the season. They have a struggling offense and a defense that has been unable to get key stops. The Giants have some key players out due to injuries, including running back Tyrone Tracy, who suffered a dislocated shoulder. Their offensive line has also struggled to protect quarterback Russell Wilson, who has been benched for rookie Jaxon Dart. This is a team in a rebuilding phase, and its struggles are likely to continue.

The Pick: Los Angeles Chargers (-6) The Chargers are a well-oiled machine, and the Giants are in disarray. This is a classic mismatch between a team on the rise and one in complete free fall. The Chargers’ offense will be too much for the Giants’ defense to handle, and the Chargers will win this game handily.

• Spread: Chargers -6
• Moneyline: Chargers -231, Giants +318
• Total: 44

Sunday, September 28: Philadelphia Eagles at Tampa Bay Buccaneers

• Venue: Raymond James Stadium, Tampa, Florida
• Date: Sunday, September 28, 2025
• Time: 1:00 PM ET

Team Analysis and Betting Breakdown

The Philadelphia Eagles are a perfect 3-0 on the season and are coming off a thrilling comeback win against the Rams. The Eagles have a dominant offense and a defense that can make big plays when it matters most. However, they’ve had some close calls, and their secondary has appeared vulnerable at times. They are facing a tough test on the road against a Bucs team that is also undefeated.

The Tampa Bay Buccaneers are also a perfect 3-0. They have been able to win close games, including a last-second victory over the Jets in Week 3. Quarterback Baker Mayfield has been impressive, and their offense has been surprisingly effective. They have a huge injury concern with wide receiver Mike Evans, who left the game with a hamstring injury and is questionable for this game. His status is a huge factor for the Bucs’ offense.

The Pick: Philadelphia Eagles (-3.5). This is a battle of two undefeated teams, but the Eagles are the more complete team. The Eagles’ offense is too talented, and the Buccaneers’ injury to Mike Evans is a huge blow. Even if he plays, he won’t be 100%. The Eagles will be able to exploit the Bucs’ secondary and get out of Tampa Bay with a win and a cover.

• Spread: Eagles -3.5
• Moneyline: Eagles -187, Bucs +145
• Total: 43.5

Sunday, September 28: Tennessee Titans at Houston Texans

• Venue: NRG Stadium, Houston, Texas
• Date: Sunday, September 28, 2025
• Time: 1:00 PM ET

Team Analysis and Betting Breakdown

The Tennessee Titans are in a bad place, sitting at 0-3 on the season after a 41-20 loss to the Colts. Their offense has been a significant disappointment, and they have struggled to move the ball consistently. They are also dealing with several injuries, including their star running back, who is out with a lingering hamstring injury. Their defense has also been unable to get key stops.

The Houston Texans are also 0-3, coming off a 17-10 loss to the Jaguars. Their offense has also struggled, and they have not been able to score consistently. The Texans are a young team, and they are still searching for their identity. They have a few injuries to monitor, but they are a relatively healthy team.

The Pick: Houston Texans (-7). This is a game between two teams who are in a bad spot. However, the Texans are playing at home, and they are a more talented team on paper. The Titans’ offense is a disaster, and I don’t see them scoring enough points to win this game. The Texans will get their first win of the season and cover the spread.

• Spread: Texans -7
• Moneyline: Texans -360, Titans +260
• Total: 40.5

Sunday, September 28: Indianapolis Colts at Los Angeles Rams

• Venue: SoFi Stadium, Inglewood, California
• Date: Sunday, September 28, 2025
• Time: 4:05 PM ET

Team Analysis and Betting Breakdown

The Indianapolis Colts are a surprising 3-0 on the season. Quarterback Daniel Jones has been a revelation, and their offense has been putting up big numbers. The Colts’ defense has also been playing well, making key stops. They have a couple of injuries to monitor, but they are a relatively healthy team.

The Los Angeles Rams are coming off a tough 33-26 loss to the Eagles, in which they blew a late lead. They have a talented offense with a great quarterback and several playmakers. They are also playing at home, which is a huge advantage. However, their defense has been vulnerable, and they have struggled to stop the run.

The Pick: Los Angeles Rams (-4) The Rams are a better team than their record suggests. They are a talented team with a good offense, and they are playing at home. The Colts are a good team, but they have been playing above their heads. Expect the Rams to score on the Colts and secure a much-needed win and cover.

• Spread: Rams -4
• Moneyline: Rams -202, Colts +156
• Total: 49

Sunday, September 28: Jacksonville Jaguars at San Francisco 49ers

• Venue: Levi’s Stadium, Santa Clara, California
• Date: Sunday, September 28, 2025
• Time: 4:05 PM ET

Team Analysis and Betting Breakdown

The Jacksonville Jaguars are coming off a gritty 17-10 win over the Texans. They have a solid offense and a good defense, and they are a well-coached team. However, they are facing a tough matchup on the road against one of the best teams in the NFL. They have a relatively clean injury report, which is a significant advantage.

The San Francisco 49ers are a perfect 3-0, and they are coming off a tough 16-15 win over the Cardinals. Their offense has been impressive, and their defense is elite. They are playing at home, which is a huge advantage. However, they have been dealing with some injuries to their quarterbacks, and they will need to monitor the status of Brock Purdy and Mac Jones this week.

The Pick: San Francisco 49ers (-3) The 49ers are a Super Bowl contender, and the Jaguars are a good team, but they are not on the same level. The 49ers’ defense will be too much for the Jaguars’ offense to handle, and the 49ers’ offense will be able to score enough points to win this game easily. I’m picking the 49ers to win and cover.

• Spread: 49ers -3
• Moneyline: 49ers -187, Jaguars +145
• Total: 47

Sunday, September 28: Baltimore Ravens at Kansas City Chiefs

• Venue: Arrowhead Stadium, Kansas City, Missouri
• Date: Sunday, September 28, 2025
• Time: 4:25 PM ET

Team Analysis and Betting Breakdown

The Baltimore Ravens are coming off a tough 20-17 loss to the Eagles and a “non-forecasted” 38-30 loss to the Lions. They have a talented offense and a defense that can be dominant. They are a well-coached team and a legitimate contender for the Super Bowl. However, they are facing a tough test on the road against the reigning Super Bowl champs.

The Kansas City Chiefs are in a tough spot, sitting at 0-2 on the season after a 20-17 loss to the Eagles. Quarterback Patrick Mahomes is dealing with his first three-game losing streak in the NFL, and the Chiefs’ offense has looked out of sync. They are playing at home and will be motivated to secure their first win of the season. The Chiefs have a few injuries to monitor, but they are a relatively healthy team.

The Pick: Kansas City Chiefs (+2.5) This is a tough one to pick, but I’m going with the Chiefs. The Chiefs have been playing poorly, but they are too talented to be 0-3. They are playing at home and will be motivated to secure their first win. I expect Patrick Mahomes to have a vast game and lead the Chiefs to a win and a cover.

• Spread: Ravens -2.5
• Moneyline: Ravens -149, Chiefs +117
• Total: 48

Sunday, September 28: Chicago Bears at Las Vegas Raiders

• Venue: Allegiant Stadium, Las Vegas, Nevada
• Date: Sunday, September 28, 2025
• Time: 4:25 PM ET

Team Analysis and Betting Breakdown

The Chicago Bears are coming off a shocking 31-14 win over the Cowboys, in which quarterback Caleb Williams threw four touchdowns. It was a huge win for them, and they demonstrated considerable potential. However, they are still a young team, and they have struggled on defense. They will need to play well on both sides of the ball to get a win on the road.

The Las Vegas Raiders are coming off a tough 41-24 loss to the Commanders. Their offense has been inconsistent, and their defense has struggled to get key stops. The Raiders have a few injuries to monitor, but they are a relatively healthy team. They are playing at home, which is a huge advantage.

The Pick: Chicago Bears (-1) The Bears are a young and exciting team, and they are playing with a lot of confidence after their huge win over the Cowboys. The Raiders have been inconsistent, and their defense has looked vulnerable. The Bears should be able to score on the Raiders and get a win and a cover.

• Spread: Bears -1
• Moneyline: Bears -110, Raiders -115
• Total: 48

Sunday, September 28: Green Bay Packers at Dallas Cowboys

• Venue: AT&T Stadium, Arlington, Texas
• Date: Sunday, September 28, 2025
• Time: 8:20 PM ET

Team Analysis and Betting Breakdown

The Green Bay Packers are coming off their first loss of the season, a 13-10 defeat to the Browns. The Packers’ offense struggled, and they were unable to score a touchdown. However, they are still a very talented team with a good offense and a solid defense. They are facing a tough test on the road against a divisional rival. Analyzing the Green Bay Packers’ predictions for this game will be key.

The Dallas Cowboys are in a bad spot after a shocking 31-14 loss to the Bears. Their offense was a major disappointment, and their defense was unable to stop the Bears’ offense. The Cowboys have suffered a major injury to star wide receiver CeeDee Lamb, who has sustained a high ankle sprain and is expected to miss up to four weeks. This is a huge blow to their offense and will make it much harder for them to move the ball. The Cowboys are a team in disarray, and they will have a tough time securing a win against a motivated Packers team.

The Pick: Green Bay Packers (-7). The Packers are a better team than their performance in Week 3 suggests. They will be motivated to bounce back with a huge win, and they are facing a Cowboys team that is in a complete freefall. The Cowboys’ offense is a mess without CeeDee Lamb, and their defense has looked vulnerable. Expect the Packers to get an early lead and never look back. I’m picking the Packers to win and cover. For more NFL Predictions on this matchup, check out our site.

• Spread: Packers -7
• Moneyline: Packers -348, Cowboys +251
• Total: 47

Monday Night Football, September 29: New York Jets at Miami Dolphins

• Venue: Hard Rock Stadium, Miami Gardens, Florida
• Date: Monday, September 29, 2025
• Time: 7:15 PM ET

Team Analysis and Betting Breakdown

The New York Jets are struggling, sitting at 0-3 on the season. They are coming off a heartbreaking 29-27 loss to the Buccaneers, in which they had a blocked field goal returned for a touchdown. The Jets’ offense has been a major disappointment, consistently struggling to score points. They also have a major injury to quarterback Justin Fields, who is in concussion protocol, and his status for this game is unknown. The Jets are a team in disarray, and they will have a tough time securing a win on the road.

The Miami Dolphins are also struggling, sitting at 0-3 on the season. They are coming off a 33-27 loss to the Patriots, in which they showed some fight but were unable to get the win. The Dolphins’ offense has performed better than expected, but their defense has struggled to make key stops. The Dolphins are playing at home, which is a huge advantage.

The Pick: Miami Dolphins (-2.5). This is a game between two bad teams, but the Dolphins are the better team. The Jets’ offense is a mess, and they are dealing with a major injury to their quarterback. The Dolphins’ offense has been moving the ball well, and they will be able to score enough points to win this game. I’m picking the Dolphins to get their first win and cover the spread.

• Spread: Dolphins -2.5
• Moneyline: Dolphins -155, Jets +121
• Total: 44.5

Monday, September 29: Cincinnati Bengals at Denver Broncos

• Venue: Empower Field at Mile High, Denver, Colorado
• Date: Monday, September 29, 2025
• Time: 8:15 PM ET

Team Analysis and Betting Breakdown

The Cincinnati Bengals are in a tough spot, sitting at 2-1 on the season after a 48-10 loss to the Vikings. Their offense was a complete disaster, and they were unable to move the ball. The Bengals have a major injury to star quarterback Joe Burrow, who is out with an undisclosed injury. Their backup quarterback has looked bad, and the Bengals’ offense is a major concern.

The Denver Broncos are coming off a 23-20 loss to the Chargers. They have a solid offense and a good defense, and they are a well-coached team. They are playing at home, which is a huge advantage. They have a few injuries to monitor, but they are a relatively healthy team.

The Pick: Denver Broncos (-7). The Bengals’ offense is a complete disaster without Joe Burrow. Their backup quarterback has looked terrible, and I don’t see them scoring enough points to win this game. The Broncos are a solid team, and they will be able to score enough points to win this game and cover the spread.

• Spread: Broncos -7
• Moneyline: Broncos -370, Bengals +265
• Total: 44

The Season is Heating Up and the Odds are Taking Shape

Week 4 presents a fantastic opportunity for bettors to capitalize on the early-season trends and overreactions. The lines are tight, but our analysis of each matchup’s dynamics, from injury reports to Week 3 performance, gives you the edge.

We’ve broken down every game and provided our top picks, including the best NFL odds for each. Don’t miss out on the action. Sign up today and place your bets with confidence on all of our NFL predictions and other top picks. Let’s make this a winning week!

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