Week 16 NFL Odds & Betting Preview: Rams vs Seahawks
The NFC West lead, and potentially the No. 1 seed in the NFC, are on the line in Thursday Night Football as the 11-3 Los Angeles Rams visit the 11-3 Seattle Seahawks. Kickoff is set for 8:15 p.m. ET at Lumen Field, with early NFL odds pricing the Rams as slight road favorites at -1 (-116) and a total sitting in the mid-40s.
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Latest Betting Odds – Spread, Moneyline & Total
| BUSR | Rams | Seahawks |
| Spread | -1 | +1 |
| Moneyline | -116 | -105 |
| Total | O 44 | U 44 |
NFL Odds updated as of Tuesday, December 16, 2025.
Rams Overview – Form, Trends & Key Factors
Recent Form
The Los Angeles Rams are peaking at the right time, currently riding a two-game winning streak that pushed their record to 11-3. They are coming off a high-octane 41-34 victory over the Detroit Lions. In that contest, they put up 24 points in the second half alone.
ATS (Against the Spread) Trends
- – Road Dominance: The Rams are 5-2 straight up on the road this season and 11-2 ATS in their last 13 road games.
- – Betting Momentum: They are 10-4 ATS overall on the season and 7-2 ATS in their last nine games.
- – Ownership of the Rivalry: Los Angeles is 8-2 ATS (7-3 outright) in their last 10 games against Seattle.
- – Divisional Success: The Rams hold a 3-1 record against NFC West opponents this season.
Key Injuries & Impact
- – Davante Adams (WR): The star wide receiver is listed as questionable.
- – Impact: Without Adams, the passing attack will funnel even more heavily through Puka Nacua.
Strengths & Weaknesses
- – Elite Quarterback Play: Matthew Stafford is playing at an MVP level. He has thrown multiple touchdown passes in a league-high 12 games this season and boasts a 112.2 passer rating.
- – Red Zone Efficiency: The Rams offense is finishing drives with touchdowns, evidenced by their 41-point outburst last week.
- – Secondary Vulnerability: While the offense is elite, giving up 34 points to the Lions suggests the defense can be scored upon in shootouts.
Seahawks Overview – Form, Trends & Key Factors
Recent Form
The Seattle Seahawks enter this matchup on a four-game winning streak and are 11-3. However, their latest victory was far from pretty. They squeaked past the Indianapolis Colts 18-16, becoming the first team this season to win a game without scoring a single touchdown.
ATS Trends
- – Home Field: Seattle is 5-2 straight up at home, though only 4-3 ATS at Lumen Field.
- – Recent Form: Like the Rams, the Seahawks are 10-4 ATS overall this season and 7-2 ATS in their last nine contests.
- – Head-to-Head Struggles: Seattle is 0-5 ATS in their last five home games against the Rams.
- – Divisional Record: They are currently 2-2 against NFC West opponents.
Key Injuries
- – Charles Cross (LT): The starting left tackle is dealing with a hamstring injury and was a non-participant in practice.
Strengths & Weaknesses
- – Defensive Dominance: The Seahawks’ defense has been their backbone, holding the Colts to 16 points and keeping the team in games when the offense struggles.
- – Special Teams: Kicker Jason Myers is a legitimate weapon, setting a franchise record with six field goals last week, including a 56-yard game-winner.
- – Slow Starts: The offense has a bad habit of sleepwalking early, managing only 80 yards in the first half last week.
Head-to-Head History
- – All-Time Series: The series is deadlocked at 28-28.
- – Last Meeting: The Rams defeated the Seahawks 21-19 earlier this season in November.
- – Quarterback History: Sam Darnold has struggled mightily against Los Angeles in his career, holding a 1-4 record against the Rams.
Matchup Breakdown – Offense vs Defense
When the Rams Have the Ball
- – Stafford vs. Seattle Secondary: Matthew Stafford has been surgical, completing 66.4% of his passes for 3,722 yards and 37 touchdowns this season. He faces a Seattle defense that picked off Sam Darnold four times in their last meeting, but Stafford protects the ball much better, with only 5 interceptions on the year.
- – Puka Nacua vs. Coverage: With Davante Adams likely out, Nacua becomes the engine. He has 102 receptions for 1,367 yards this season. Last week, he exploded for 9 catches and 181 yards.
- – Rushing Lanes: The Rams may look to balance the attack, but their passing game efficiency (112.2 rating for Stafford) suggests they will attack through the air.
When the Seahawks Have the Ball
- – Turnover Roulette: The offense lives and dies by the volatility of Sam Darnold. While he is capable of elite production (22 TDs), he also leads the NFL with 16 turnovers.
- – The JSN Funnel: The passing attack has a clear “Alpha” target in Jaxon Smith-Njigba. Leading the NFL with 1,541 receiving yards and 25 explosive plays (20+ yards), he is the first, second, and third option in this scheme.
- – Explosive Ceiling: Despite recent slow starts, Seattle has proven they can blow teams out, having won a league-high 5 games by 20+ points this season.
Over/Under Analysis & Betting Trends
- – The Total: 44 Points.
- – Pace Trends: The Rams are coming off a game with 75 total points, while the Seahawks played a game with 34 total points.
- – Weather Impact: The game is outdoors in Seattle in December, likely in the rain, which could slow down the passing attacks and favor the Under.
- – Style of Play: Seattle’s defense and special teams style drags games into low-scoring fights, while the Rams prefer a shootout. The weather and venue favor Seattle’s preferred pace.
Best Prop Bets
- – Puka Nacua Over Receiving Yards: With Davante Adams expected to miss the game, Nacua’s volume is virtually guaranteed. He had 181 yards last week and is the clear focal point of the offense.
- – Matthew Stafford Passing Touchdowns: The line is set at 1.5 TDs. Stafford is averaging 2.6 passing touchdowns per game this season, with 37 total touchdowns through 14 games.
- – Sam Darnold Over Interceptions: Darnold threw 4 interceptions in the first meeting against the Rams and leads the league in turnovers.
- – Blake Corum Over 40.5 Rushing Yards: Corum is averaging 44.4 rushing yards per game this season, which provides a 3.9-yard cushion over Thursday’s line of 40.5.
Prediction & Best Bet
Pick: Rams -1.5
Why: This game comes down to trust in the quarterback position and red-zone efficiency. Matthew Stafford is playing MVP-level football, throwing for 368 yards and 2 touchdowns last week against a tough Lions team. In contrast, Sam Darnold and the Seahawks offense failed to score a single touchdown against the Colts and have a history of turnover issues against this Rams defense.
Despite the hostile environment and Davante Adams’s injury, the Rams have the superior ability to finish drives with seven points rather than three. The Seahawks’ reliance on field goals is unsustainable against an offense capable of scoring 41 points. Los Angeles has already proven they can beat Seattle this year, and Stafford’s stability (5 INTs all year vs. Darnold’s 11) will be the difference in a tight divisional battle.
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