3 Best Bets: Eagles vs Cowboys NFL Kickoff

The 2025 NFL season officially begins tonight, and what better way to start than with an NFC East showdown between the defending Super Bowl champions, the Philadelphia Eagles, and their long-time rivals, the Dallas Cowboys.

Philadelphia comes in as the clear favorite at -463 on the moneyline, with the spread sitting at Eagles -8.5. The over/under is set at 47.5 points. That number has been climbing since the summer, largely because of Dallas’ defensive shakeup after trading away star pass rusher Micah Parsons.

Even with those changes, Dallas isn’t walking in empty-handed. The Cowboys expect to have Trevon Diggs and Tyler Guyton back in the lineup tonight, which provides a boost on both sides of the ball.

Let’s break down the three best bets for this primetime matchup.

1. Over 47.5 Points

This game has all the makings of a high-scoring opener. The Eagles return one of the most explosive offenses in the league, featuring Jalen Hurts, Saquon Barkley, A.J. Brown, DeVonta Smith, and Dallas Goedert. Last season, Philadelphia finished top 10 in yards and top 5 in points per game, and much of that core remains intact behind a strong offensive line.

Meanwhile, the Cowboys’ defense is in transition. Losing Parsons takes away their biggest threat in the pass rush, and it’s difficult to imagine Dallas slowing down Philly’s balanced attack. On the other side, Dak Prescott now has an upgraded arsenal, including newly acquired George Pickens to pair with CeeDee Lamb, which should help Dallas keep pace on the scoreboard.

Expect fireworks in this one — the over is the play.

2. Dak Prescott Over 249.5 Passing Yards

If Dallas is going to compete, it will be through the air. The Cowboys’ running game remains questionable, leaving Prescott as the centerpiece of the offense. Historically, Prescott has had success against Philadelphia, holding a 9-4 career record versus the Eagles with 24 TDs and just 8 INTs.

Last season, these two teams combined for 75 total points across their meetings, and with Philadelphia’s defense losing several key starters in the offseason, Prescott should have opportunities to pile up yards. Add in the likelihood of a pass-heavy game script if the Eagles take control early, and the over on Prescott’s passing total looks strong.

3. Eagles Moneyline (-463)

The Eagles enter the season with championship swagger and a roster that still looks capable of dominating. Their Super Bowl run last year featured double-digit playoff wins and a statement victory over the Chiefs in the final.

The offensive firepower remains, and even though the defense has lost some veterans, it’s still a group that can hold up against most teams. Dallas will be competitive, but with questions in the trenches and the loss of their best defensive player, it’s hard to see them spoiling Philly’s banner night at Lincoln Financial Field.

Philadelphia on the moneyline is a safe and reliable bet to anchor your plays.

Final Thoughts

Opening night is always unpredictable, but this Eagles vs. Cowboys matchup should deliver plenty of points and highlight-reel plays. Our three best bets for the NFL Kickoff Game are:

• Over 47.5 Total Points

• Dak Prescott Over 249.5 Passing Yards

• Eagles Moneyline (-463)

You can lock in all your NFL Kickoff wagers right here at BUSR.