NFL Preseason Odds Week 2: All the Games

NFL
August 12, 2025

Betting the Preseason: A Guide to NFL Preseason Odds for Week 2

 

Welcome back, football fans and bettors! The NFL preseason is in full swing, and with Week 1’s dust settled, we have our first glimpses of what teams might look like in the upcoming season. While the preseason is a different beast from the regular season, it provides a unique opportunity for sharp bettors to find value. Coaching philosophies, quarterback battles, and roster depth all play a critical role in how these games unfold, which is why a deep dive into the NFL preseason odds is essential. We saw some interesting trends in Week 1, with underdogs covering the spread and overs hitting at a high rate. Understanding these trends and individual team situations is key to making informed NFL preseason betting decisions. Let’s break down the Week 2 slate and analyze each matchup, giving you the information you need to tackle the NFL preseason odds with confidence.

 

Philadelphia Eagles at Cleveland Browns

Venue, Date, and Time

This AFC–NFC matchup takes place at Lincoln Financial Field in Philadelphia, Pennsylvania. Kickoff is scheduled for Saturday, August 16, 2025, at 1:00 p.m. ET.

Expected Weather

The weather forecast for Philadelphia on Saturday calls for a partly cloudy day with temperatures in the mid-80s. A slight chance of rain exists, but it is unlikely to be a significant factor in the game.

Philadelphia Eagles Analysis

The Eagles enter this game as the slight favorite, sitting at a -3 point spread with a moneyline of -164. The over/under for the game is set at 38 points. The Eagles are a popular pick for Super Bowl 60, with odds of +690, tied for the best in the league. Head coach Nick Sirianni typically approaches the preseason with caution, often resting his starters. We saw that in Week 1, and it’s a trend we can expect to continue. This strategy prioritizes player health and cohesion, which is a big reason for their high regular-season expectations. However, with limited starters playing, their preseason games can be unpredictable. When betting on the Eagles, you’re essentially betting on the performance of their depth, which is still a strong suit for the team, especially with a solid backup quarterback situation.

Cleveland Browns Analysis

The Browns are the underdog in this one, with a moneyline of +133 and a +3 point spread. The Browns’ preseason performance often hinges on which quarterbacks get the most reps. With the team still navigating their quarterback situation, we can expect to see plenty of their rookie signal-caller. A lot of young players will get a chance to prove themselves, making the Browns a wild card in preseason games. Their regular-season prospects are more measured, with their offensive points total projected among the lowest in the league. This game is an excellent opportunity for their backups and rookies to make a statement, but it also creates an element of uncertainty for bettors.

 

Houston Texans at Carolina Panthers

Venue, Date, and Time

The Houston Texans will travel to Bank of America Stadium in Charlotte, North Carolina. The game is scheduled for Saturday, August 16, 2025, at 1:00 p.m. ET.

Expected Weather

The forecast for Charlotte on game day anticipates clear skies and warm temperatures in the high 80s. The weather should not impact the game.

Houston Texans Analysis

The Texans are a slight road favorite, with a -3 point spread and a moneyline of -168. The over/under is set at 38.5 points. Houston is a team on the rise with a strong young core. They’ve made some key offseason moves to bolster their roster, but they’ll likely use the preseason to evaluate their depth and give their second and third-string players significant playing time. This approach makes them a formidable preseason opponent as they try to finalize their roster. For the regular season, the Texans have playoff aspirations, and this preseason is a crucial part of their preparation. Their NFL preseason odds reflect a team with a solid foundation, even if they won’t be playing their starters for long.

Carolina Panthers Analysis

The Panthers come into this game as the underdog, with a moneyline of +136 and a +3 point spread. The Panthers will use the preseason to integrate their young talent and solidify their offense under new leadership. We can expect to see their starters for a series or two, giving them an early look at their latest schemes. The Panthers have a lot to prove this season, and their preseason performance will be a bellwether for their regular-season chances. Their regular-season win total is one of the lowest in the league, reflecting their ongoing rebuild. Betting on the Panthers in the preseason means trusting their young talent and coaching staff to get the most out of their players in a meaningful way.

 

Green Bay Packers at Indianapolis Colts

Venue, Date, and Time

The Packers will visit the Colts at Lucas Oil Stadium in Indianapolis, Indiana. The game is set for Saturday, August 16, 2025, at 1:00 p.m. ET.

Expected Weather

This game will take place inside a domed stadium, so the weather will not be a factor.

Green Bay Packers Analysis

The Packers are the road underdog, with a moneyline of +216 and a +6 point spread. The over/under is set at 40.5 points. The Packers are looking to build on their impressive regular-season performance last year, and their preseason will focus on developing their younger players. They are a team with a clear plan, and they will want to avoid any injuries to their key starters. This game offers its backups an opportunity to shine and compete for a spot on the 53-man roster. Their regular-season outlook is positive, with a competitive team that can make a deep run. For bettors, the Packers’ preseason approach makes them an interesting play, as their backups are often motivated to perform.

Indianapolis Colts Analysis

The Colts are the strong favorite in this contest, with a -6 point spread and a moneyline of -275. The Colts will look to establish their offensive and defensive systems in a meaningful way during the preseason. With a talented roster, the Colts are a team to watch in their conference. They have a solid offensive unit and a defense that can make plays, which should give them an advantage over the Packers’ backups. The Colts’ regular-season prospects are solid, and they have the potential to surprise some people. For NFL preseason odds to bet on, the Colts’ strong home-field advantage and a more established roster could make them a good bet.

 

New England Patriots at Minnesota Vikings

Venue, Date, and Time

The Patriots will travel to U.S. Bank Stadium in Minneapolis, Minnesota. The game is scheduled for Saturday, August 16, 2025, at 1:00 p.m. ET.

Expected Weather

This game will also take place in a domed stadium, so the weather is not a factor.

New England Patriots Analysis

The Patriots are the slight favorite, with a -2.5 point spread and a moneyline of -137. The over/under is set at 39 points. With a new head coach, the Patriots are in a state of transition. We can expect to see their new coaching staff try to implement their system and assess their personnel. This means their preseason games will be more intense than for other teams. The Patriots are a team to watch, and their regular-season outlook is one of cautious optimism. The new head coach will want to establish a winning culture from the start, which could mean a more focused effort in the preseason. This makes them a more appealing bet than teams that rest all their key players.

Minnesota Vikings Analysis

The Vikings are the home underdog, with a moneyline of +112 and a +2.5 point spread. The Vikings have a lot of talented players, but they will use the preseason to fine-tune their schemes and get their backups up to speed. Their quarterback situation is also one to watch, as they continue to develop their young signal-caller. The Vikings have a strong home-field advantage and a passionate fan base, which could give them an extra boost even in a preseason game. Their regular-season expectations are high, and this preseason is a vital step in their preparation. Bettors looking at NFL preseason odds for this game should consider the Vikings’ home-field advantage and the motivation of their backups.

 

San Francisco 49ers at Las Vegas Raiders

Venue, Date, and Time

This game will take place at Allegiant Stadium in Las Vegas, Nevada. Kickoff is scheduled for Saturday, August 16, 2025, at 4:00 p.m. ET.

Expected Weather

This game will take place inside a domed stadium, so the weather will not be a factor.

San Francisco 49ers Analysis

The 49ers are the underdog, with a moneyline of +192 and a +5.5 point spread. The over/under is set at 40.5 points. The 49ers are a team with Super Bowl aspirations, and they prioritize keeping their starters healthy for the regular season. This means their preseason games often feature many backups and rookies. However, their depth is still substantial, and their coaching staff is excellent at getting the most out of their players. The 49ers’ focus is on the long game, not on winning preseason contests. This makes them a tricky team to bet on, as their performance can vary greatly depending on who is on the field.

Las Vegas Raiders Analysis

The Raiders are the favorite, with a -5.5 point spread and a moneyline of -242. The Raiders have some question marks on their roster, and their preseason will be about finding the right combinations and developing their talent. They will likely give their backups and rookies a lot of playing time, making this an important game for their roster decisions. For the regular season, the Raiders face a tough road, and their preseason performance could be a sign of things to come. The Raiders are a team with a lot of motivation to perform well, which could give them an edge in this game. For NFL preseason odds, bet on the Raiders’ strong home-field advantage and focus on building their roster, which makes them a compelling pick.

 

Baltimore Ravens at Dallas Cowboys

Venue, Date, and Time

The Ravens will visit the Cowboys at AT&T Stadium in Arlington, Texas. The game is scheduled for Saturday, August 16, 2025, at 7:00 p.m. ET.

Expected Weather

This game will take place inside a domed stadium, so the weather will not be a factor.

Baltimore Ravens Analysis

The Ravens are a slight favorite, with a -2 point spread and a moneyline of -126. The over/under is set at 37 points. The Ravens are a perennial contender, and their preseason approach is often about maintaining continuity and getting their backups ready. They have one of the deepest rosters in the league, which makes them a formidable opponent even in the preseason. Their veteran coaching staff knows how to prepare a team, and they will have their players ready to compete. The Ravens are a popular pick to make a deep playoff run, and their preseason games will be a chance for their backups to prove they belong.

Dallas Cowboys Analysis

The Cowboys are the home underdog, with a moneyline of +103 and a +2 point spread. The Cowboys have a lot of talent, but they also have some questions to answer, especially on offense. They will use the preseason to get their players on the same page and work out any kinks. This is a big game for their young players, who will be competing for a spot on the team. The Cowboys take great pride, and they will want to put on a good show for their home fans. Their regular-season prospects are solid, but they need a strong preseason to build momentum. The Cowboys’ motivation to perform in front of their home crowd makes them an interesting NFL preseason odds choice to pick.

 

Los Angeles Chargers at Los Angeles Rams

Venue, Date, and Time

The Battle of LA takes place at SoFi Stadium in Inglewood, California. The game is scheduled for Saturday, August 16, 2025, at 7:00 p.m. ET.

Expected Weather

This game will also take place inside a domed stadium, so the weather will not be a factor.

Los Angeles Chargers Analysis

The Chargers are the favorite in this contest, with a -4 point spread and a moneyline of -212. The over/under is set at 37.5 points. The Chargers are a team with a new head coach, and they will be using the preseason to get their players accustomed to his system. This means their preseason games will be more focused on execution and player development. The Chargers have a lot of talent, and they are a team to watch in their conference. Their regular-season prospects are strong, and they have the potential to make a deep run. For bettors, the Chargers’ new coaching staff and motivated players make them a strong contender in this game.

Los Angeles Rams Analysis

The Rams are the home underdog, with a moneyline of +170 and a +4 point spread. The Rams have a veteran team, and they will use the preseason to evaluate their depth and prepare their backups. They have a lot of veteran leaders who can help guide the younger players, which makes them a formidable opponent even with their starters on the sideline. Their regular-season expectations are high, and they are a team with a clear plan. The Rams will be looking to get their players into game shape and build some chemistry before the regular season begins. Betting on the Rams means trusting their coaching staff and veteran leadership to get the most out of their backups.

 

New York Jets at New York Giants

Venue, Date, and Time

The battle for New York will take place at MetLife Stadium in East Rutherford, New Jersey. Kickoff is scheduled for Saturday, August 16, 2025, at 7:00 p.m. ET.

Expected Weather

The forecast for East Rutherford on Saturday is for partly cloudy skies and temperatures in the low 80s. The weather should not be a factor.

New York Jets Analysis

The Jets are the underdog in this game, with a moneyline of +167 and a +3.5 point spread. The over/under is set at 39.5 points. The Jets have a lot of talent and a lot of hype, but they also have some questions to answer. Their preseason will be all about getting their players on the same page and building chemistry. They have a lot of young players who will be competing for a spot on the roster, which makes this an important game for their future. The Jets’ regular-season prospects are high, and their preseason is a critical part of their preparation. This is a great opportunity for their backups to make a statement.

New York Giants Analysis

The Giants are the home favorite, with a -3.5 point spread and a moneyline of -208. The Giants are a team in transition, and they will use the preseason to evaluate their roster and get their players ready for the regular season. They have a new coaching staff, and they will be looking to implement their system and find the right combinations. The Giants’ regular-season expectations are more measured, and their preseason is a vital part of their development. This is an excellent opportunity for their young players to prove they belong. For bettors, the Giants’ home-field advantage and motivated players make them an interesting play.

 

Tampa Bay Buccaneers at Pittsburgh Steelers

Venue, Date, and Time

The Buccaneers will travel to Acrisure Stadium in Pittsburgh, Pennsylvania. The game is scheduled for Saturday, August 16, 2025, at 7:00 p.m. ET.

Expected Weather

The forecast for Pittsburgh on game day is for partly cloudy skies and temperatures in the mid-80s. The weather should not be a factor.

Tampa Bay Buccaneers Analysis

The Buccaneers are the favorite in this contest, with a -2 point spread and a moneyline of -180. The over/under is set at 40 points. The Buccaneers are a team with a solid core and a veteran coaching staff. Their preseason will be about getting their players into game shape and fine-tuning their schemes. The Buccaneers are a team with high expectations for the regular season, and this preseason is a vital part of their preparation. Their backups are motivated to perform, which could give them an advantage in this game. For bettors, the Buccaneers’ solid roster and veteran leadership make them a strong pick.

Pittsburgh Steelers Analysis

The Steelers are the home underdog, with a moneyline of +102 and a +2 point spread. The Steelers are a team with a new offensive system, and they will use the preseason to get their players accustomed to the latest schemes. Their preseason will be all about development and finding the right combinations. The Steelers’ regular-season prospects are solid, and their preseason is a critical part of their preparation. They have a passionate fan base, and they will want to put on a good show for their home crowd. This makes them a motivated team in the preseason, which could give them an edge.

 

Arizona Cardinals at Denver Broncos

Venue, Date, and Time

The Cardinals will visit the Broncos at Empower Field at Mile High in Denver, Colorado. Kickoff is scheduled for Saturday, August 16, 2025, at 9:30 p.m. ET.

Expected Weather

The forecast for Denver on game day is for a mix of sun and clouds with temperatures in the low 80s. The elevation of Denver could play a factor in the game, but it’s a minor one.

Arizona Cardinals Analysis

The Cardinals are the underdog in this game, with a moneyline of +180 and a +4.5 point spread. The over/under is set at 40 points. The Cardinals are a team during a rebuild, and their preseason will be all about evaluating their young talent and finding the right combinations. They have a lot of young players who will be competing for a spot on the roster, which makes this an important game for their future. The Cardinals’ regular-season prospects are low, but their preseason is a vital part of their development. This is a great opportunity for their backups to make a statement.

Denver Broncos Analysis

The Broncos are the strong favorite, with a -4.5 point spread and a moneyline of -226. The Broncos are a team with a new head coach who is known for taking the preseason seriously. They will be looking to implement his system and get their players accustomed to his style of play. This means their preseason games will be more focused on execution and player development. The Broncos have a lot of talent, and they are a team to watch in their conference. Their regular-season prospects are solid, and they have the potential to surprise some people. For bettors, the Broncos’ new coaching staff and a motivated team make them a strong contender in this game.

 

Jacksonville Jaguars at New Orleans Saints

Venue, Date, and Time

The Jaguars will visit the Saints at Caesars Superdome in New Orleans, Louisiana. The game is scheduled for Sunday, August 17, 2025, at 1:00 p.m. ET.

Expected Weather

This game will take place inside a domed stadium, so the weather will not be a factor.

Jacksonville Jaguars Analysis

The Jaguars are the favorite in this contest, with a -1 point spread and a moneyline of -115. The over/under is set at 40 points. The Jaguars are a team with a lot of talent, and their preseason will be about getting their players into game shape and fine-tuning their schemes. They have a lot of young players who will be competing for a spot on the roster, which makes this an important game for their future. The Jaguars’ regular-season prospects are high, and their preseason is a vital part of their preparation. For bettors, the Jaguars’ solid roster and veteran leadership make them a strong pick.

New Orleans Saints Analysis

The Saints are the home underdog, with a moneyline of +106 and a +1 point spread. The Saints are a team with a lot of veteran leaders, but they also have some questions to answer, especially on offense. They will use the preseason to get their players on the same page and work out any kinks. Their regular-season expectations are more measured, and their preseason is a vital part of their development. This is an excellent opportunity for their young players to prove they belong. The Saints’ home-field advantage and a motivated team make them an interesting play.

 

Buffalo Bills at Chicago Bears

Venue, Date, and Time

The Bills will travel to Soldier Field in Chicago, Illinois. Kickoff is scheduled for Sunday, August 17, 2025, at 8:00 p.m. ET.

Expected Weather

The forecast for Chicago on game day is for partly cloudy skies and temperatures in the low 80s. The weather should not be a factor.

Buffalo Bills Analysis

The Bills are the favorite in this game, with a moneyline of -115 and a -1 point spread. The over/under is set at 40 points. The Bills are a perennial contender, and their preseason approach is often about maintaining continuity and getting their backups ready. They have one of the deepest rosters in the league, which makes them a formidable opponent even in the preseason. Their veteran coaching staff knows how to prepare a team, and they will have their players ready to compete. The Bills are a popular pick to make a deep playoff run, and their preseason games will be a chance for their backups to prove they belong.

Chicago Bears Analysis

The Bears are the home underdog, with a +1 point spread and a moneyline of -106. The Bears are a team on the rise, and their preseason will be about getting their players on the same page and building chemistry. They have a new offensive coordinator, and they will be looking to implement his system and get their players accustomed to his style of play. This means their preseason games will be more focused on execution and player development. The Bears’ regular-season prospects are solid, and they have the potential to make a deep run. The Bears’ motivation to perform in front of their home crowd makes them a strong contender in this game.

 

Cincinnati Bengals at Washington Commanders

Venue, Date, and Time

The Bengals will travel to Northwest Stadium in Landover, Maryland. Kickoff is scheduled for Monday, August 18, 2025, at 8:00 p.m. ET.

Expected Weather

The forecast for Landover on Monday is for partly cloudy skies and temperatures in the low 80s. The weather should not be a factor.

Cincinnati Bengals Analysis

The Bengals are the strong favorite, with a -4.5 point spread and a moneyline of -236. The over/under is set at 42.5 points. The Bengals are a team with Super Bowl aspirations, and they prioritize keeping their starters healthy for the regular season. This means their preseason games often feature many backups and rookies. However, their depth is still strong, and their coaching staff is excellent at getting the most out of their players. The Bengals’ focus is on the long game, not on winning preseason contests. This makes them a tricky team to bet on, as their performance can vary greatly depending on who is on the field.

Washington Commanders Analysis

The Commanders are the home underdog, with a moneyline of +188 and a +4.5 point spread. The Commanders are a team during a rebuild, and their preseason will be all about evaluating their young talent and finding the right combinations. They have a new head coach and a lot of new players, which makes this an important game for their future. The Commanders’ regular-season prospects are low, but their preseason is a vital part of their development. This is a great opportunity for their backups to make a statement and show they belong in the NFL.

 

The Final Takeaway: A High-Octane Week 2 Awaits!

 

The preseason may not impact the standings, but it’s where futures are built and fortunes are earned. The unpredictability of these matchups, driven by fierce roster battles and strategic coaching, offers a unique and exciting opportunity for bettors. We’ve laid out the details for every game this weekend, giving you a comprehensive view of the landscape. From the motivated underdogs to the deep-roster favorites, every game has a story and a chance to cash in.

Now it’s your turn to get in on the action. Don’t just watch the games, invest in the knowledge we’ve provided. The time to sign up and seize your winning moment is now. Our extensive analysis of NFL preseason odds is just the beginning. Head to BUSR, use this breakdown to guide your decisions, and place your bets with confidence. The thrill of the NFL is back, and so are the opportunities to win big. Don’t miss out on this golden chance to get in on the NFL preseason betting action. Let’s make some money!

 

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