NFL Week 2 Early Odds and Picks: Your Guide to a Winning Weekend

NFL
September 10, 2025

After an exhilarating opening week, the NFL landscape has already shifted. We saw statement wins, shocking upsets, and a few teams that left us scratching our heads. Now, as we turn our attention to Week 2, the stakes are even higher. Teams will either build on their early momentum or desperately fight to avoid a 0-2 start. The NFL betting lines are live, and we’re breaking down every single matchup, giving you the deep analysis and sharp picks you need to dominate your wagers. Let’s look at the best NFL odds and get into the action.

 

Thursday Night Football

 

Green Bay Packers at Washington Commanders

Venue: FedExField, Landover, MD Date & Time: September 14, 2025, 1:00 p.m. ET

Green Bay Packers Analysis

The Green Bay Packers started their season strong, getting a convincing win. Jordan Love looked sharp, throwing for over 250 yards and a couple of touchdowns. The passing attack was dynamic, and multiple players contributed. Their running game, a crucial part of their identity, was also effective. Defensively, they were opportunistic and created key turnovers. They are a complete team on both sides of the ball. The only question mark is the health of wide receiver Christian Watson, who missed some practice time this week, but early reports suggest he will be good to go. The Green Bay Packers’ predictions are high for this young team.

Washington Commanders Analysis

The Washington Commanders lost their Week 1 matchup and showed some signs of struggle on offense. Jayden Daniels had a respectable outing, but they did not score enough points to win. Their defense played a decent game, holding their opponent in check for most of the second half, but they couldn’t get a crucial stop when they needed it. They face a formidable opponent in the Packers, who come in full of confidence. The Commanders will need to generate more pressure on the quarterback and force turnovers to have a chance. They are significant underdogs for a reason, but at home, they could make things interesting.

NFL Odds for the Game:

  • Spread: Packers -3.5
  • Moneyline: Packers -183 / Commanders +148
  • Total: 48

BUSR Pick: Green Bay is the superior team, and their Week 1 performance proved they are ready to contend. I expect Jordan Love to have another strong game against a Washington defense that will be fighting for every yard. Pick the Packers to cover the spread.

 

Sunday Night Football

 

New York Giants at Dallas Cowboys

Venue: AT&T Stadium, Arlington, TX Date & Time: September 11, 2025, 8:20 p.m. ET

New York Giants Analysis

The New York Giants did not have the start they envisioned, falling to a division rival. Their offense looked stagnant for much of the game, and Russell Wilson, in his new home, had a tough time finding a rhythm. He completed just over 50% of his passes, and the team struggled to sustain drives. The running game, however, showed some promise, with the backfield providing a decent spark. Defensively, they fought hard but couldn’t make a crucial stop when it mattered most. Injuries could be a factor, with reports suggesting running back Devin Singletary’s status is in question after a late-game scare. They need to find a way to get Wilson comfortable and put points on the board to have a chance against the high-powered Cowboys.

Dallas Cowboys Analysis

The Dallas Cowboys are coming off a surprising loss to the Eagles, but their offense, despite the result, looked potent. Dak Prescott threw for over 300 yards and two touchdowns, and the team moved the ball with efficiency. However, their defense, which we expected to be a strength, struggled mightily against Philadelphia’s attack, particularly on the back end. This is a critical point for the Cowboys. Their Week 1 loss exposed some vulnerabilities. They will be looking to re-establish their dominance at home against a less-than-stellar Giants offense. Look for them to pressure Wilson and force him into mistakes, something their defensive line is more than capable of doing.

NFL Odds for the Game:

  • Spread: Cowboys -6
  • Moneyline: Cowboys -265 / Giants +208
  • Total: 44.5

BUSR Pick: The Cowboys bounce back at home. We are confident in their offense’s ability to exploit the Giants’ defense, and we expect their defense to perform better. Pick the Cowboys to cover the spread.

 

Chicago Bears at Detroit Lions

Venue: Ford Field, Detroit, MI Date & Time: September 14, 2025, 1:00 p.m. ET

Chicago Bears Analysis

The Chicago Bears started their season with a loss, and the offense struggled to find its footing under new coach Ben Johnson. Quarterback Caleb Williams had a few rookie moments, and the receiving corps, led by DJ Moore, couldn’t consistently get open. The running game was also a non-factor. It’s a challenging task to get the season back on track, and facing his old team in Detroit adds an extra layer of pressure for coach Johnson. They will need to play mistake-free football and find a way to create explosive plays, something they failed to do in Week 1. This is a tough spot for the Bears. The Detroit Lions’ Predictions are probably already looking good for the home team.

Detroit Lions Analysis

The Detroit Lions looked impressive in their Week 1 victory, showing why they are a top contender in the NFC. Jared Goff was efficient, completing over 70% of his passes, and the offense spread the ball around to multiple playmakers. The running game was effective and balanced, keeping the opposing defense guessing. Defensively, they were stout, creating pressure and forcing turnovers. They enter this game with a clear advantage in talent and experience. The crowd in Detroit will be electric, and the team will be eager to make a statement against a divisional rival. Their early-season performance sets them up as a strong contender.

NFL Odds for the Game:

  • Spread: Lions -5.5
  • Moneyline: Lions -265 / Bears +206
  • Total: 47

BUSR Pick: Detroit is simply the better, more experienced team right now. Their offense is clicking, and their defense is playing with a ferocity we have not seen in past seasons. Expect them to take advantage of the Bears’ young quarterback and win by a comfortable margin. Pick the Lions to cover the spread.

 

 

 

Buffalo Bills at New York Jets

Venue: MetLife Stadium, East Rutherford, NJ Date & Time: September 14, 2025, 1:00 p.m. ET

Buffalo Bills Analysis

The Buffalo Bills looked fantastic in their season opener, putting up a considerable number of points and demonstrating a well-rounded offensive attack. Josh Allen was sensational, and the running game was firing on all cylinders. Their defense, a trademark of the Sean McDermott era, was equally impressive, holding their opponent to just a handful of points. The Bills are a complete team and a legitimate Super Bowl contender. They have no significant injury concerns and come into this game with complete confidence.

New York Jets Analysis

The New York Jets started their season on a sour note, and their offense struggled to get anything going. Their quarterback threw for less than 150 yards and had two interceptions. They lacked a punch on offense and looked discombobulated. Defensively, they are still strong, but they cannot win games if their offense cannot move the ball. The Jets need to find a way to score points, or it will be a long season for them. They have talent on both sides of the ball, but they have to put it all together.

NFL Odds for the Game:

  • Spread: Bills -6.5
  • Moneyline: Bills -315 / Jets +244
  • Total: 46.5

BUSR Pick: Buffalo is a machine. They have a dominant offense and a stellar defense. The Jets, on the other hand, look lost on offense and will have a hard time keeping up with the Bills’ scoring. I don’t see this one being close. Pick the Bills to cover the spread.

 

Jacksonville Jaguars at Cincinnati Bengals

Venue: Paycor Stadium, Cincinnati, OH Date & Time: September 14, 2025, 1:00 p.m. ET

Jacksonville Jaguars Analysis

The Jaguars pulled off a hard-fought victory in Week 1, and their offense showed some flashes of brilliance. Trevor Lawrence was solid, and the running game was a pleasant surprise. Their defense, however, gave up some big plays and looked vulnerable at times. They will need to tighten up on that side of the ball if they want to hang with a team like the Bengals. The Jacksonville Jaguars are a good team, but they are not in the same class as the elite teams in the league. They will have to play their best game to beat the Bengals at home.

Cincinnati Bengals Analysis

The Cincinnati Bengals, led by Joe Burrow, are a powerhouse on offense, but they struggled in their opener. They managed to win, but Burrow had a rough outing. He will be looking to get back on track at home, and the Jaguars’ defense could be the perfect remedy. Their defense, which has been a strength in recent years, also had a mixed bag performance. They will need to play at a high level to stop the Jaguars’ offense.

NFL Odds for the Game:

  • Spread: Bengals -3.5
  • Moneyline: Bengals -187 / Jaguars +151
  • Total: 48.5

BUSR Pick: We expect a Joe Burrow bounce-back game. The Bengals’ offense is too talented to struggle for two straight weeks. They will come out firing and put up a considerable number. Pick the Bengals to cover the spread.

 

New England Patriots at Miami Dolphins

Venue: Hard Rock Stadium, Miami Gardens, FL Date & Time: September 14, 2025, 1:00 p.m. ET

New England Patriots Analysis

The Mike Vrabel era in New England got off to a rocky start. The New England Patriots‘ offense, led by rookie quarterback Drake Maye, struggled to move the ball and score points. The defense was solid, but they could not get a crucial stop when they needed it. The Patriots are a rebuilding team, and they will have their fair share of growing pains. They face a tough road test in Miami, and they will need to play a near-perfect game to win.

Miami Dolphins Analysis

The Dolphins’ offense looked terrible in their Week 1 loss. Tua Tagovailoa struggled to protect the football, and the offense could not get into a rhythm. This offense is built on speed and quick passes, but they looked slow and predictable. Their defense, a strength last season, also had a rough outing. They will be looking to get back on track at home against a rookie quarterback. This is a must-win game for the Miami Dolphins if they want to prove they are a legitimate contender.

NFL Odds for the Game:

  • Spread: Dolphins -1
  • Moneyline: Dolphins -118 / Patriots +104
  • Total: 43.5

BUSR Pick: This is a tough one, but I am going with the Dolphins. They are a better team on paper, and they are at home. They will be desperate for a win after their Week 1 embarrassment. We expect their offense to improve and their defense to perform better. Pick the Dolphins to cover the spread.

 

Los Angeles Rams at Tennessee Titans

Venue: Nissan Stadium, Nashville, TN Date & Time: September 14, 2025, 1:00 p.m. ET

Los Angeles Rams Analysis

The Rams looked strong in their Week 1 victory. Matthew Stafford was in command of the offense, and the team scored points at a rapid pace. Kyren Williams looked explosive, and the defense played well. The Los Angeles Rams are a solid team, and they are ready to compete in the NFC. They have a tough road test in Tennessee, but they are more than capable of handling it.

Tennessee Titans Analysis

The Titans lost their Week 1 matchup, and their offense looked stagnant. They could not score points, and their quarterback struggled to move the ball. Their defense played a solid game, but they could not hold up forever. The Tennessee Titans are a rebuilding team, and they will have their fair share of struggles. They are at home, but they are facing a much better team. I don’t see them having a chance against the Rams.

NFL Odds for the Game:

  • Spread: Rams -5.5
  • Moneyline: Rams -255 / Titans +202
  • Total: 42

BUSR Pick: The Rams are a much better team than the Titans, and they are playing with a lot of confidence. Expect them to go on the road and win by a comfortable margin. Pick the Rams to cover the spread.

 

San Francisco 49ers at New Orleans Saints

Venue: Caesars Superdome, New Orleans, LA Date & Time: September 14, 2025, 1:00 p.m. ET

San Francisco 49ers Analysis

The San Francisco 49ers got a much-needed win in Week 1, but it wasn’t pretty. Brock Purdy, their starting quarterback, is dealing with a shoulder and toe injury that could keep him out of this game. If he can’t go, the 49ers will turn to Mac Jones, whom they signed in the offseason. The good news is their defense is still elite, and they have a talented roster. They will have to rely on their running game and defense to win this game. They will be without George Kittle, who is out with a hamstring injury.

New Orleans Saints Analysis

The Saints lost their Week 1 matchup, and their offense looked out of sync. Derek Carr struggled to move the ball, and they could not score points. Their defense played a decent game, but they could not get a key stop when they needed it. The Saints are a team with a lot of talent, but they have to put it all together. They will have to take advantage of the 49ers’ injuries if they want to win this game.

NFL Odds for the Game:

  • Spread: 49ers -4.5
  • Moneyline: 49ers -230 / Saints +183
  • Total: 42

BUSR Pick: The 49ers are a better team, even with their injuries. Their defense is elite, and they have a strong running game. They will likely be able to control the clock and win a low-scoring game. Pick the 49ers to cover the spread.

 

Seattle Seahawks at Pittsburgh Steelers

Venue: Acrisure Stadium, Pittsburgh, PA Date & Time: September 14, 2025, 1:00 p.m. ET

Seattle Seahawks Analysis

The Seahawks lost their Week 1 matchup, and their offense looked out of sync. Geno Smith struggled to move the ball, and they could not score points. Their defense played a decent game, but they could not get a key stop when they needed it. The Seattle Seahawks are a team with a lot of talent, but they have to put it all together. They will face a tough road test in Pittsburgh, and they will have to play a near-perfect game to win.

Pittsburgh Steelers Analysis

The Steelers got a big win in Week 1, and Aaron Rodgers looked like he was reborn. He threw for over 240 yards and four touchdowns, and the offense looked dynamic. Their defense played a solid game, creating pressure and forcing turnovers. The Pittsburgh Steelers are a legitimate contender in the AFC, and they are playing with a lot of confidence. They are at home, facing a struggling Seahawks team. I expect them to dominate this game.

NFL Odds for the Game:

  • Spread: Steelers -3
  • Moneyline: Steelers -159 / Seahawks +129
  • Total: 40

BUSR Pick: The Steelers are a much better team, and Aaron Rodgers is playing at an elite level. Expect them to dominate this game and win by a comfortable margin. Pick the Steelers to cover the spread.

 

Cleveland Browns at Baltimore Ravens

Venue: M&T Bank Stadium, Baltimore, MD Date & Time: September 14, 2025, 1:00 p.m. ET

Cleveland Browns Analysis

The Cleveland Browns lost a tough one in Week 1, and their offense struggled to move the ball. Deshaun Watson struggled to get into a rhythm, and they could not score points. Their defense, a strength last season, also had a rough outing. The Browns have a lot of talent, but they have to put it all together. They face a tough road test in Baltimore, and they will need to play their best game to win.

Baltimore Ravens Analysis

The Ravens lost a heartbreaker in Week 1, but their offense looked explosive. Lamar Jackson had a huge game, throwing for over 300 yards and a couple of touchdowns. Their defense, however, gave up some big plays and looked vulnerable at times. The Baltimore Ravens are a legitimate Super Bowl contender, and they are at home. Expect them to come out firing and put up a considerable number.

NFL Odds for the Game:

  • Spread: Ravens -11.5
  • Moneyline: Ravens -1019 / Browns +622
  • Total: 45

BUSR Pick: The Ravens are a much better team, and they are at home. Expect Lamar Jackson to have another huge game and their defense to step up. This is a mismatch. Pick the Ravens to cover the spread.

 

Denver Broncos at Indianapolis Colts

Venue: Lucas Oil Stadium, Indianapolis, IN Date & Time: September 14, 2025, 4:05 p.m. ET

Denver Broncos Analysis

The Denver Broncos secured a much-needed win in Week 1, with their offense performing well. Bo Nix had a solid debut, and the running game was effective. Their defense played well, creating pressure and forcing turnovers. The Broncos are a solid team, and they are playing with a lot of confidence. They face a tough road test in Indianapolis, but they are more than capable of handling it.

Indianapolis Colts Analysis

The Colts also won their Week 1 matchup, and their offense looked much improved with Daniel Jones at quarterback. They moved the ball with efficiency and scored points. Their defense also played a decent game. The Indianapolis Colts are a team on the rise, and they are at home. This is a tough matchup, and I expect it to be a close game.

NFL Odds for the Game:

  • Spread: Broncos -2
  • Moneyline: Broncos -128 / Colts +105
  • Total: 42.5

BUSR Pick: This is a tough one to call, but I am going with the Broncos. They have a good coach and a solid roster. They will likely be able to control the clock and win a low-scoring game. Pick the Broncos to cover the spread.

 

Carolina Panthers at Arizona Cardinals

Venue: State Farm Stadium, Glendale, AZ Date & Time: September 14, 2025, 4:05 p.m. ET

Carolina Panthers Analysis

The Panthers lost a tough one in Week 1, and their offense looked terrible. Bryce Young struggled to move the ball, and they could not score points. Their defense played a decent game, but they could not get a key stop when they needed it. The Carolina Panthers are a rebuilding team, and they will have their fair share of struggles. They face a tough road test in Arizona, and they will need to play a near-perfect game to win.

Arizona Cardinals Analysis

The Arizona Cardinals got a much-needed win in Week 1, and their offense looked explosive. Kyler Murray had a huge game, and the running game was effective. Their defense also played a decent game. The Cardinals are a legitimate NFC contender, and they are at home. I expect them to dominate this game.

NFL Odds for the Game:

  • Spread: Cardinals -6.5
  • Moneyline: Cardinals -290 / Panthers +226
  • Total: 44.5

BUSR Pick: The Cardinals are a much better team, and Kyler Murray is playing at an elite level. Expect them to dominate this game and win by a comfortable margin. Pick the Cardinals to cover the spread.

 

Philadelphia Eagles at Kansas City Chiefs

Venue: GEHA Field at Arrowhead Stadium, Kansas City, MO Date & Time: September 14, 2025, 4:25 p.m. ET

Philadelphia Eagles Analysis

The Eagles got a huge win in Week 1, and their offense looked incredible. Jalen Hurts had a monster game, and the team scored points at a rapid pace. Their defense, however, gave up some big plays and looked vulnerable at times. The Philadelphia Eagles are a legitimate Super Bowl contender, and they are playing with a lot of confidence. They face a tough road test in Kansas City, but they are more than capable of handling it.

Kansas Chiefs Analysis

The Chiefs lost a tough one in Week 1, and their offense looked stagnant. Patrick Mahomes struggled to get into a rhythm, and they could not score points. Their defense played a decent game, but they could not get a key stop when they needed it. The Kansas City Chiefs are a team with a lot of talent, but they have to put it all together. They are at home, and they will be desperate for a win.

NFL Odds for the Game:

  • Spread: Eagles -1
  • Moneyline: Eagles -120 / Chiefs -103
  • Total: 47

BUSR Pick: This is the game of the week, and it is a tough one to call. Both teams are talented, but we are going with the Eagles. They are playing with more confidence, and their offense looks more explosive. I expect a close game, but the Eagles will pull out the victory. Pick the Eagles to win.

 

Atlanta Falcons at Minnesota Vikings

Venue: U.S. Bank Stadium, Minneapolis, MN Date & Time: September 14, 2025, 8:20 p.m. ET

Atlanta Falcons Analysis

The Atlanta Falcons lost their Week 1 matchup, and their offense looked out of sync. Kirk Cousins struggled to move the ball, and they could not score points. Their defense played a decent game, but they could not get a key stop when they needed it. The Falcons are a team with a lot of talent, but they have to put it all together. They face a tough road test in Minnesota, and they will need to play a near-perfect game to win.

Minnesota Vikings Analysis

The Vikings got a much-needed win in Week 1, and their offense looked solid. They moved the ball with efficiency and scored points. Their defense also played a decent game. The Minnesota Vikings are a team on the rise, and they are at home. This is a tough matchup, and I expect it to be a close game.

NFL Odds for the Game:

  • Spread: Vikings -4
  • Moneyline: Vikings -204 / Falcons +165
  • Total: 44.5

BUSR Pick: The Vikings are a better team, and they are at home. Expect them to win by a comfortable margin. Pick the Vikings to cover the spread.

 

Monday Night Football

Tampa Bay Buccaneers at Houston Texans

Venue: NRG Stadium, Houston, TX Date & Time: September 15, 2025, 8:15 p.m. ET

Tampa Bay Buccaneers Analysis

The Buccaneers won a hard-fought game in Week 1, and their offense looked good. Baker Mayfield played well, and the team scored points. Their defense played a decent game, but they could not get a key stop when they needed it. The Tampa Bay Buccaneers are a solid team, and they are ready to compete in the NFC South. They face a tough road test in Houston, but they are more than capable of handling it.

Houston Texans Analysis

The Texans lost a tough one in Week 1, and their offense struggled to move the ball. C.J. Stroud struggled to get into a rhythm, and they could not score points. Their defense played a decent game, but they could not get a key stop when they needed it. The Houston Texans are a team with a lot of talent, but they have to put it all together. They are at home, and they will be desperate for a win.

NFL Odds for the Game:

  • Spread: Texans -3
  • Moneyline: Texans -150 / Buccaneers +123
  • Total: 42.5

BUSR Pick: This is a tough one to call, but I am going with the Buccaneers. They are playing with more confidence, and their offense looks more explosive. Expect a close game, but the Buccaneers will pull out the victory. Pick the Buccaneers to win.

 

Los Angeles Chargers at Las Vegas Raiders

Venue: Allegiant Stadium, Las Vegas, NV Date & Time: September 15, 2025, 8:15 p.m. ET

Los Angeles Chargers Analysis

The Los Angeles Chargers got a massive win in Week 1, and their offense looked explosive. Justin Herbert had a monster game, and the team scored points at a rapid pace. Their defense, however, gave up some big plays and looked vulnerable at times. The Chargers are a legitimate contender in the AFC, and they are playing with a lot of confidence. They face a tough road test in Las Vegas, but they are more than capable of handling it.

Las Vegas Raiders Analysis

The Raiders also won their Week 1 matchup, and their offense looked solid. They moved the ball with efficiency and scored points. Their defense also played a decent game. The Las Vegas Raiders are a team on the rise, and they are at home. This is a tough matchup, and expect it to be a close game.

NFL Odds for the Game:

  • Spread: Chargers -3.5
  • Moneyline: Chargers -185 / Raiders +154
  • Total: 47

BUSR Pick: The Chargers are a better team, and Justin Herbert is playing at an elite level. I expect them to win by a comfortable margin. Pick the Chargers to cover the spread.

 

The Overreact Week is Here, and the NFL Odds are set

 

Week 2 of the NFL season is shaping up to be an exciting one. With every game, the stakes get higher and the narratives become more compelling. From a bounce-back game for the Cowboys to a test of strength for the Lions and Packers, this is the week we really start to learn what teams are made of. You have the tools, the analysis, and the picks. Now, it’s your turn to get in on the action. The NFL odds are waiting.

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