NFL Week 3 Early Odds: A Complete Guide to Every Game on the Slate

NFL
September 15, 2025

The NFL Season is Taking Shape, and it’s time to bet

 

Welcome back, football fans and savvy bettors! The NFL season is officially in full swing, and with the chaos of the first two weeks behind us, Week 3 presents a new set of challenges and opportunities. We’ve seen superstars get hurt, underdog stories emerge, and some of the league’s most prominent names stumble out of the gate. This is where the season’s narratives truly begin to form, and for those who love online football betting, it’s where the most value can be found.

From the high-stakes AFC East showdown on Thursday Night Football to a classic NFC North rivalry and a potential Super Bowl preview on Monday, the Week 3 schedule is loaded with can’t-miss matchups. We’re breaking down every game, providing you with the most current NFL odds, and giving you the smart betting angles you need to make informed decisions. So, let’s get into the action and get ready to bet on the NFL with BUSR.

 

Thursday Night Football, Sept. 18

Miami Dolphins at Buffalo Bills

  • Game Background & Key Players: This AFC East rivalry is a tale of two teams. The Bills have looked dominant, starting 2-0 with QB Josh Allen playing at an MVP level. Their offense is explosive, and the defense has been solid. The Dolphins, meanwhile, are in a freefall at 0-2. QB Tua Tagovailoa has struggled, and the team seems to be in disarray.
  • Odds Breakdown & Smart Betting Angles:
    • Point Spread: Bills -12.5
    • Moneyline: Bills -826, Dolphins +562
    • Over/Under: 46.5
    • Insights: The line has ballooned from an opener of Bills -8.5, a clear sign of the betting public’s lack of faith in Miami. The Bills are 2-0 against the spread (ATS) and have an average margin of victory of 10.5 points. Betting on the Bills to cover the -12.5 spread is a strong play, as it’s hard to see the Dolphins keeping this close. The Bills’ offense is simply too much for Miami’s struggling defense.

 

Sunday Night Football, Sept. 21

Green Bay Packers at Cleveland Browns

  • Game Background & Key Players: The Packers, coming off a Thursday night game, have a rest advantage and have started 2-0 with the NFL odds in their favor, looking like a legitimate NFC contender. QB Jordan Love is playing brilliantly, and the defense has been a major factor. The Browns are 0-2 and have been a disappointment, with their offense looking lackluster.
  • Odds Breakdown & Smart Betting Angles:
    • Point Spread: Packers -8.5
    • Moneyline: Packers -452, Browns +349
    • Over/Under: 42.5
    • Insights: The line has moved from Packers -5.5 to -8.5, reflecting Green Bay’s impressive start and Cleveland’s struggles. The Packers have covered both of their spreads this season. Look for the Packers to continue their winning ways and cover the -8.5 spread on the road.

Houston Texans at Jacksonville Jaguars

  • Game Background & Key Players: Both teams are trying to find their footing in the AFC South. The Texans are 0-1 and have struggled on offense. The Jaguars are 1-1, but their offense has been inconsistent.
  • Odds Breakdown & Smart Betting Angles:
    • Point Spread: Jaguars -1.5
    • Moneyline: Texans -101, Jaguars -119
    • Over/Under: 43.5
    • Insights: The line has flipped from an opener of Texans -1.5 to Jaguars -1.5, suggesting the public is backing Jacksonville after their Week 2 win. This is a challenging game to bet, but a prop bet on the total could be smart. The Under 43.5 seems appealing given both offenses’ early-season struggles.

New Orleans Saints at Seattle Seahawks

  • Game Background & Key Players: Both teams are coming off a loss and are looking for a bounce-back win. The Saints are 0-2, and the offense has yet to find a rhythm. The Seahawks, at 1-1, are trying to establish an identity with their new head coach.
  • Odds Breakdown & Smart Betting Angles:
    • Point Spread: Seahawks -7
    • Moneyline: Saints +302, Seahawks -380
    • Over/Under: 41.5
    • Insights: The Seahawks are favored at home by a full touchdown, suggesting the oddsmakers believe in their ability to shut down a struggling Saints offense. The Seahawks -7 is a high-risk, high-reward bet. However, the Under 41.5 seems like a safer option given both teams’ defensive prowess and offensive inconsistencies.

Tennessee Titans at Indianapolis Colts

  • Game Background & Key Players: The Colts are a surprise at 2-0, with a dominant defense and a strong running game. The Titans are 0-2 and have had a difficult start to the season, particularly on offense.
  • Odds Breakdown & Smart Betting Angles:
    • Point Spread: Colts -3.5
    • Moneyline: Colts -168, Titans +143
    • Over/Under: 43.5
    • Insights: This line has flipped entirely from an opener of Titans -1.5. The Colts have been covering their spreads and have an average margin of victory of 12 points. The Colts -3.5 is a solid value pick. The Over/Under has also dropped, but with the Colts’ running game, they could easily chew up the clock.

Arizona Cardinals at San Francisco 49ers

  • Game Background & Key Players: The Cardinals are a stunning 2-0 to start the season, while the 49ers, at 2-0, are showing why they are a Super Bowl contender. This is a battle for NFC West supremacy.
  • Odds Breakdown & Smart Betting Angles:
    • Point Spread: Cardinals -1.5
    • Moneyline: Cardinals -115, 49ers -104
    • Over/Under: 43.5
    • Insights: This line is a pick’em, which shows the respect the Cardinals have earned. While the 49ers are a tough team to bet against, the Cardinals have been proving all the doubters wrong. The Cardinals’ Moneyline (-115) is a great value play here.

Atlanta Falcons at Carolina Panthers

  • Game Background & Key Players: The Falcons are 1-1 and have shown flashes of a potent offense with Bijan Robinson and a defense that can make plays. The Panthers are 0-2, and their offense has been inconsistent.
  • Odds Breakdown & Smart Betting Angles:
    • Point Spread: Falcons -3.5
    • Moneyline: Falcons -188, Panthers +157
    • Over/Under: 43.5
    • Insights: This line has flipped, with the Falcons now road favorites. The public is backing the Falcons’ defensive performance from Week 2. The Falcons -3.5 is a good bet, especially if their defense can force some turnovers.

Los Angeles Rams at Philadelphia Eagles

  • Game Background & Key Players: A matchup of two undefeated teams. The Eagles are 2-0 and look to be a dominant force, led by their star-studded offense. The Rams are also 2-0, with QB Matthew Stafford looking sharp. This is a test for both teams.
  • NFL Odds Breakdown & Smart Betting Angles:
    • Point Spread: Eagles -3.5
    • Moneyline: Rams +179, Eagles -217
    • Over/Under: 45.5
    • Insights: The Eagles are a tough team to beat at home, and the -3.5 spread seems reasonable. The over/under is also a solid bet here. Both teams have explosive offenses, and a high-scoring game is likely.

Pittsburgh Steelers at New England Patriots

  • Game Background & Key Players: The Steelers are 1-1 and trying to get on track, while the Patriots are 1-1 after a surprise win. Both teams are looking to find their identity this season.
  • NFL Odds Breakdown & Smart Betting Angles:
    • Point Spread: Steelers -1.5
    • Moneyline: Steelers -113, Patriots -106
    • Over/Under: 44.5
    • Insights: This game is a pick’em, indicating the oddsmakers have little confidence in either team. The Patriots at +1.5 at home is a decent value bet. The Over 44.5 is a strong play, given both teams’ offensive weapons.

Kansas City Chiefs at New York Giants

  • Game Background & Key Players: The Chiefs are in crisis mode, starting 0-2 for the first time in the Patrick Mahomes era. The Giants are also 0-2, but have shown flashes of a competitive team.
  • Odds Breakdown & Smart Betting Angles:
    • Point Spread: Chiefs -5.5
    • Moneyline: Chiefs -265, Giants +216
    • Over/Under: 43.5
    • Insights: The Chiefs are still a favorite, despite their record. This is a must-win game for Kansas City, and a bet on the Chiefs -5.5 is a safe bet. The Chiefs have a lot of pride, and they’ll be motivated to get a win here.

Las Vegas Raiders at Washington Commanders

  • Game Background & Key Players: The Raiders are 1-0 and coming off their bye week, looking to build on their momentum. The Commanders are 1-1, with a young quarterback at the helm.
  • Odds Breakdown & Smart Betting Angles:
    • Point Spread: Commanders -5.5
    • Moneyline: Raiders +222, Commanders -273
    • Over/Under: 47.5
    • Insights: The Commanders are a firm favorite at home. The Over 47.5 is a great bet here. Both teams have the potential for high-scoring games, and this could be a shootout.

Denver Broncos at Los Angeles Chargers

  • Game Background & Key Players: The Broncos are 1-1 and have been playing well. The Chargers are 1-0 and have looked good on offense.
  • NFL Odds Breakdown & Smart Betting Angles:
    • Point Spread: Chargers -2.5
    • Moneyline: Broncos +118, Chargers -138
    • Over/Under: 43.5
    • Insights: This game is a toss-up, and the Chargers’ Moneyline (-138) is a decent value bet. The Chargers have a slight advantage with home-field and a solid offense.

Cincinnati Bengals at Minnesota Vikings

  • Game Background & Key Players: The Bengals’ NFL Odds have been significantly impacted by the injury to QB Joe Burrow, who is out indefinitely with a turf toe injury. Jake Browning will be the starter. The Vikings are 1-1 and have a strong defense.
  • Odds Breakdown & Smart Betting Angles:
    • Point Spread: Vikings -3.5
    • Moneyline: Bengals +160, Vikings -192
    • Over/Under: 42.5
    • Insights: The line has moved from a pick’em to Vikings -3.5, showing the impact of the Burrow injury. The Vikings -3.5 is a strong play. The Bengals’ offense will be severely hampered, and the Vikings’ defense is good enough to limit them.

Dallas Cowboys at Chicago Bears

  • Game Background & Key Players: The Cowboys are 1-1 and have a high-powered offense. The Bears are 0-2 and are desperate for a win.
  • Odds Breakdown & Smart Betting Angles:
    • Point Spread: Bears -1.5
    • Moneyline: Cowboys -107, Bears -112
    • Over/Under: 48.5
    • Insights: This is a pick’em, which shows how uncertain this game is. The Cowboys Moneyline (-107) is a good value play here. The Cowboys’ offense is too talented not to get on track.

New York Jets at Tampa Bay Buccaneers

  • Game Background & Key Players: The Jets are 0-2 and have struggled on both sides of the ball. The Buccaneers are 1-0 and are looking to build on their early-season momentum.
  • Odds Breakdown & Smart Betting Angles:
    • Point Spread: Buccaneers -7
    • Moneyline: Jets +256, Buccaneers -321
    • Over/Under: 44.5
    • Insights: The Buccaneers are a full touchdown favorite, indicating a lack of confidence in the Jets. The Buccaneers -7 is a great bet.

 

Monday Night Football, Sept. 22

Detroit Lions at Baltimore Ravens

  • Game Background & Key Players: This is the most anticipated matchup of the week. The Lions are 1-1 and have a high-powered offense led by Jared Goff. The Ravens are 1-1, and the NFL odds are on top, and Lamar Jackson is playing at an MVP level. This is an actual test for both teams.
  • Odds Breakdown & Smart Betting Angles:
    • Point Spread: Ravens -5.5
    • Moneyline: Lions +214, Ravens -265
    • Over/Under: 51.5
    • Insights: This is the highest total of the week, and for good reason. Both teams have elite offenses, and the potential for a shootout is high. The Over 51.5 is a powerful bet.

 

How & Where to Bet NFL Online. Why BUSR is the Go-To

 

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Don’t Miss Your Chance to Bet on the NFL with BUSR

 

NFL Week 3 is shaping up to be a fascinating slate of games with potential playoff implications and plenty of storylines. From the desperate Dolphins to the injured Bengals and the red-hot Bills, there’s no shortage of things to watch and bet on. The lines are set, the matchups are ready, and the excitement is building. Whether you’re a fan of point spreads, moneylines, or prop bets, BUSR has everything you need to get in on the action.

Don’t just watch the games—make them matter. The NFL season is a marathon, but every week is a sprint, and Week 3 is a crucial turning point. Visit BUSR today, analyze the NFL odds, and place your online football betting wagers now.

 

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