Week 6 NFL Early Odds: The Betting Guide for Every Game on the Slate

NFL
October 6, 2025

Welcome back, football fans and savvy bettors! The NFL season is gaining steam, and with the first five weeks behind us, Week 6 offers another fresh slate of opportunities. Injuries, momentum swings, and underdog stories continue to reshape the landscape. This is where value bets emerge, narratives evolve, and sharp bettors can get an edge.

From Thursday Night’s NFC East clash to a Sunday London tilt and a primetime showdown in Kansas City, the Week 6 schedule is stacked. Below, you’ll find early odds for every game and smart betting angles to keep in mind. Let’s dive in.

 

Thursday Night Football, Oct. 9

 

Philadelphia Eagles at New York Giants

Spread: Eagles –7.5
Moneyline: Eagles –400, Giants +285
Over/Under: 41.5

 

Betting Angle

This is a pivotal divisional matchup. The Eagles are looking to bounce back after their first loss, while the Giants have been prone to turnovers. The line is steep, but Eagles –7.5 is tempting — especially early, before line movement. The total is modest, hinting at a defensive grind. Lean Under 41.5, especially if either offense continues to struggle in consistency.

 

Sunday Slate, Oct. 12

 

Denver Broncos at New York Jets (in London)

Spread: Broncos –7

Moneyline: Broncos –374, Jets +270

Over/Under: 43.5


Betting Angle

Denver is favored by more than a touchdown, suggesting strong early support. London games often suppress offense. If you believe the Jets can at least stay in it, Broncos –7 is aggressive but plausible. The total is tight — under could be worth a look if conditions or time zones slow the pace.

 

Cleveland Browns at Pittsburgh Steelers

Spread: Steelers –4.5

Moneyline: Steelers –242, Browns +184

Over/Under: 37.5

 

Betting Angle

The Steelers are laying a moderate number at home versus a Browns team coming off international travel. The low total suggests a slow, methodical game. Steelers –4.5 is a solid bet if you trust their run game and home-field energy. The Under is tempting given recent trends and matchup dynamics.

 

Arizona Cardinals at Indianapolis Colts

Spread: Colts –6

Moneyline: Colts –294

Over/Under: 47

 

Betting Angle

The Colts are modest favorites at home. If you believe the Cardinals’ offense is shaky, Colts –6 seems reasonable. The total is one of the higher ones on the card — consider the Over only if you expect a shootout.

 

Los Angeles Chargers at Miami Dolphins

Spread: Chargers –4

Moneyline: Chargers – 230, Dolphins +175

Over/Under: 43.5

 

Betting Angle

The Chargers are getting middling respect on the road. If their offense stays sharp, -4 is fair value. The total is in the middle range — the Over has upside if both teams push the tempo.

 

Los Angeles Rams at Baltimore Ravens

Spread: Rams –8

Moneyline: Rams –410, Ravens +290

Over/Under: 45.5

 

Betting Angle

Baltimore has significant injury concerns for week 6 NFL odds, including at quarterback, which weakens their chances of success. Rams –8 is a strong lean. The total suggests a moderate scoring; if the Ravens’ offense struggles, the Under could be in play.

 

Seattle Seahawks at Jacksonville Jaguars

Spread: Jaguars –1

Moneyline: Jacksonville -109, Seattle -116

Over/Under: 45.5

 

Betting Angle

This is a tight line, reflecting expected parity. Jaguars –1 is small but meaningful — home edge matters. The total is middle-of-the-road, so wait for the matchup or injury nuances before betting.

 

Dallas Cowboys at Carolina Panthers

Spread: Cowboys –3.5

Moneyline: Cowboys –198, Panthers +153

Over/Under: 49.5

 

Betting Angle

Dallas is favored but not overwhelmingly so. If their offensive talent is clicking, they should be able to cover. The total is higher — consider Over if both teams push the pace or if turnovers favor extended drives.

 

San Francisco 49ers at Tampa Bay Buccaneers

Spread: Buccaneers –3

Moneyline: Bucs -169, 49ers +132

Over/Under: 47.5

 

Betting Angle

This is a high-profile NFC matchup for this week’s 6 NFL odds perspective. The Bucs are slight favorites. Expect swings and back-and-forth offensive battles. Lean the side you expect to finish strong; Over 47.5 is plausible given pedigree.

 

Tennessee Titans at Las Vegas Raiders

Spread: Raiders –5

Moneyline: Raiders –246, Titans +187

Over/Under: 41

 

Betting Angle

The Raiders are moderate favorites at home. –5.5 isn’t overly aggressive. The total is among the lowest, with a strong lean toward ‘Under’, unless both offenses break out.

 

Cincinnati Bengals at Green Bay Packers

Spread: Packers –14.5

Moneyline: Packers –1,299, Bengals +680

Over/Under: 44

 

Betting Angle

This is the biggest spread of the week. The Packers –14.5 shows strong confidence from oddsmakers. If Green Bay is clicking, this is appealing. But big spreads carry risk — consider half-points or alternative bets. The total is moderate, leaning under if you expect the Bengals to struggle offensively.

 

Detroit Lions at Kansas City Chiefs (Sunday Night Football)

Spread: Chiefs –1

Moneyline: Kansas -121, Detroit -105

Over/Under: 50

 

Betting Angle

This has prime-time intrigue. The Chiefs are slight favorites at home. The total is high — one to consider over if defenses are off or both offenses are hot. Chiefs -1 is a mild lean, assuming an edge in coaching and home crowd support.

 

Monday Night Football, Oct. 13

 

Buffalo Bills at Atlanta Falcons

Spread: Bills –4

Moneyline: Bills -210, Falcons +155

Over/Under: 48.5

 

Betting Angle

Buffalo enters as the modest favorites for Week 6 NFL Odds. With the total among the highest, this one is primed for offensive fireworks. Lean Over 48.5 if both teams get rolling. Bills –4 is reasonable, especially if their defense limits big plays.

 

Betting Strategy Tips

  • Line movement matters: Early lines often shift. Take advantage of the value before the lines adjust.
  • Watch injuries & weather: Late-week changes can drastically affect totals or spreads.
  • Matchup leverage: Target games where one team’s strength aligns with the opponent’s weakness (e.g., strong run attack vs weak front seven).
  • Totals equity: Better opportunities sometimes lie in overs/unders than spreads, especially when pace or offense trends are clear.
  • Bankroll discipline: High spreads (e.g., Packers –14.5) or tight lines (e.g., Jaguars –1.5) can be tempting — size accordingly.

 

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